September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Spectral domain optical coherence tomography measurement of the retinal pigment epithelium and Bruch's membrane complex thickness, and its associations in a large population cohort, UK Biobank
Author Affiliations & Notes
  • Zaynah Ameerah Muthy
    NIHR Biomedical Research Centre, Moorfields Eye Hospital, London, United Kingdom
    UCL INSTITUTE OF OPHTHALMOLOGY, London, United Kingdom
  • Fang Ko
    NIHR Biomedical Research Centre, Moorfields Eye Hospital, London, United Kingdom
    UCL INSTITUTE OF OPHTHALMOLOGY, London, United Kingdom
  • Paul J Foster
    NIHR Biomedical Research Centre, Moorfields Eye Hospital, London, United Kingdom
    UCL INSTITUTE OF OPHTHALMOLOGY, London, United Kingdom
  • Nicholas G Strouthidis
    NIHR Biomedical Research Centre, Moorfields Eye Hospital, London, United Kingdom
    UCL INSTITUTE OF OPHTHALMOLOGY, London, United Kingdom
  • Qi Yang
    Topcon Advanced Biomedical Imaging Laboratory, Oakland, New Jersey, United States
  • Charles A Reisman
    Topcon Advanced Biomedical Imaging Laboratory, Oakland, New Jersey, United States
  • Usha Chakravarthy
    Optometry & Vision Science, Queens University of Belfast, Belfast, United Kingdom
  • Andrew J Lotery
    Ophthalmology, Southampton General Hospital, Hampshire, United Kingdom
  • Adnan Tufail
    UCL INSTITUTE OF OPHTHALMOLOGY, London, United Kingdom
    NIHR Biomedical Research Centre, Moorfields Eye Hospital, London, United Kingdom
  • Pearse Andrew Keane
    UCL INSTITUTE OF OPHTHALMOLOGY, London, United Kingdom
    NIHR Biomedical Research Centre, Moorfields Eye Hospital, London, United Kingdom
  • Praveen J Patel
    NIHR Biomedical Research Centre, Moorfields Eye Hospital, London, United Kingdom
    UCL INSTITUTE OF OPHTHALMOLOGY, London, United Kingdom
  • Footnotes
    Commercial Relationships   Zaynah Muthy, None; Fang Ko, None; Paul Foster, Alcon (R), Allergan (R), Zeiss (R); Nicholas Strouthidis, Alcon (R), Allergan (R), Heidelberg Engineering (R), Novartis (R); Qi Yang, Topcon Medical Systems (E); Charles Reisman, Topcon Medical Systems (E); Usha Chakravarthy, Allergen (C), Bayer (F), Bayer (C), Notal Vision (C), Novartis (F), Novartis (C); Andrew Lotery, None; Adnan Tufail, None; Pearse Keane, Allergan (R), Bayer (R), Heidelberg (R), Novartis (R), Topcon (R); Praveen Patel, Bayer (C), Heidelberg Inc (F), Novartis (C), SalutarisMD (R), Thrombogenics NV (C), Thrombogenics NV (F), Topcon Inc (F)
  • Footnotes
    Support  NIHR BRC2_009 (Moorfields & UCL), International Glaucoma Association (UK), Fight for Sight (UK), UCL GRS & ORS (Dr Ko), Moorfields Eye Hospital Special Trustees, Macular Disease Society (UK)
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 4267. doi:
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    • Get Citation

      Zaynah Ameerah Muthy, Fang Ko, Paul J Foster, Nicholas G Strouthidis, Qi Yang, Charles A Reisman, Usha Chakravarthy, Andrew J Lotery, Adnan Tufail, Pearse Andrew Keane, Praveen J Patel; Spectral domain optical coherence tomography measurement of the retinal pigment epithelium and Bruch's membrane complex thickness, and its associations in a large population cohort, UK Biobank. Invest. Ophthalmol. Vis. Sci. 2016;57(12):4267.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To describe the factors associated with retinal pigment epithelium-Bruch's membrane (RPE-BM) complex thickness, in a multi-site community-based study in the United Kingdom.

Methods : 67,318 people aged 40-69 years underwent questionnaire, physical and eye examination including macular SD-OCT. RPE-BM thickness was measured using Topcon Advanced Boundary Segmentation in 9 ETDRS subfields. Systematic selection process identified 34,652 eyes with high-quality SD-OCT images for analysis. We included people with no self-reported ocular disease, diabetes, or neurologic disorders, visual acuity ≥20/25, refraction within 6 diopters of emmetropia, and IOP 6-21 mmHg. Multivariable regression modelling was used to adjust for covariates, identify relationships between RPE-BM thickness, ocular and systemic features.

Results : Mean RPE-BM thickness was 26.3 μm (SD 4.8) at central subfield, with nasal (inner 27.1 μm, outer 26.9 μm) and temporal subfields (inner 26.1 μm, outer 25.6 μm) significantly thicker than superior (inner 24.5 μm, outer 24.3 μm) and inferior (inner 24.7 μm, outer 24.0 μm) subfields (all p<0.001). Multivariable regression with age stratification suggests RPE thinning becomes apparent after age 45. Among those age ≤45, RPE-BM was significantly thicker among those of black or mixed race (+3.61 and +1.77 μm vs. white, respectively; p<0.001) and in higher hyperopia (+0.4 μm/diopter, p<0.001), but not for other variables considered. Among those aged >45, RPE-BM was significantly thinner in older age (-0.10 μm/year, p<0.001), Asians (-0.45 μm vs. white, p=0.02), taller height (-0.02 μm/cm, p<0.001), higher IOP (-0.03 μm per mmHg, p<0.001), and regular smokers (-0.27 μm vs. non-smokers, p=0.02). Again, RPE-BM was thicker in black or mixed races (+3.29 μm and +0.81 μm vs. white, respectively; p<0.001), and higher hyperopes (+0.28 μm/diopter, p<0.001). There was no significant association with sex, Chinese ethnicity, nor former or occasional smoking.

Conclusions : RPE-BM thickness varies with age, ethnicity, refraction, IOP, and smoking. The novel significant association with IOP may have relevance for etiology of glaucoma. The quantification of relationships between age, ethnicity, smoking and RPE-BM are relevant to the study of age-related macular degeneration.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

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