September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Effect of Yoga and Meditation Based Intervention on Intraocular Pressure, Quality of Life, Oxidative Stress and Gene Expression Pattern in Primary Open Angle Glaucoma: A Randomized Controlled Trial.
Author Affiliations & Notes
  • Tanuj Dada
    RP CENTRE FOR OPHTHALMIC SCIENCES, NEW DELHI, AII INDIA INSTITUTE OF MEDICAL SCIENCES, NEW DELHI, NEW DELHI, India
  • Muneeb A. Faiq
    RP CENTRE FOR OPHTHALMIC SCIENCES, NEW DELHI, AII INDIA INSTITUTE OF MEDICAL SCIENCES, NEW DELHI, NEW DELHI, India
    Laboratory for Molecular Reproduction and Genetics,Department of Anatomy, All India Institute of Medical Sciences, New Delhi, Delhi, India
  • Kuldeep Mohanty
    RP CENTRE FOR OPHTHALMIC SCIENCES, NEW DELHI, AII INDIA INSTITUTE OF MEDICAL SCIENCES, NEW DELHI, NEW DELHI, India
    Laboratory for Molecular Reproduction and Genetics,Department of Anatomy, All India Institute of Medical Sciences, New Delhi, Delhi, India
  • Deepti Mittal
    RP CENTRE FOR OPHTHALMIC SCIENCES, NEW DELHI, AII INDIA INSTITUTE OF MEDICAL SCIENCES, NEW DELHI, NEW DELHI, India
  • Muzaffer Bhat
    Department of Physiology, All India Institute of Medical Sciences, New Delhi, Delhi, India
  • Raj Kumar Yadav
    Department of Physiology, All India Institute of Medical Sciences, New Delhi, Delhi, India
  • Ramanjit Sihota
    RP CENTRE FOR OPHTHALMIC SCIENCES, NEW DELHI, AII INDIA INSTITUTE OF MEDICAL SCIENCES, NEW DELHI, NEW DELHI, India
  • Rima Dada
    Laboratory for Molecular Reproduction and Genetics,Department of Anatomy, All India Institute of Medical Sciences, New Delhi, Delhi, India
  • Ravindra M Pandey
    Department of Biostatistics, All India Institute of Medical Sciences, New Delhi, Delhi, India
  • Footnotes
    Commercial Relationships   Tanuj Dada, None; Muneeb Faiq, None; Kuldeep Mohanty, None; Deepti Mittal, None; Muzaffer Bhat, None; Raj Yadav, None; Ramanjit Sihota, None; Rima Dada, None; Ravindra Pandey, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:
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      Tanuj Dada, Muneeb A. Faiq, Kuldeep Mohanty, Deepti Mittal, Muzaffer Bhat, Raj Kumar Yadav, Ramanjit Sihota, Rima Dada, Ravindra M Pandey; Effect of Yoga and Meditation Based Intervention on Intraocular Pressure, Quality of Life, Oxidative Stress and Gene Expression Pattern in Primary Open Angle Glaucoma: A Randomized Controlled Trial.. Invest. Ophthalmol. Vis. Sci. 201657(12):.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : We evaluated the effect of Yoga and Meditation based intervention (YMBI) on IOP, quality of life (QOL), stress markers, neurotrophins and gene expression in patients with primary open angle glaucoma (POAG).

Methods : Eighty POAG patients aged > 45 years on topical medical therapy with best corrected visual acuity of 20/40 or better in both eyes were randomized (40 in each YMBI and control group). Patients with any co-morbid ocular or systemic diseases, performing yoga, meditation or aerobic exercise were excluded. The intervention was a 60 minute YMBI (30 minute deep breathing and relaxation exercises and 30 minutes meditation) for 21 days supervised by a trained instructor. Parameters evaluated before and after the intervention were IOP, QOL (WHO-QOL BREF and GQL-15 questionnaires), serum levels of cortisol, β-endorphin, IL6, TNF-α, BDNF, reactive oxygen stress (ROS), total antioxidant capacity (TAC) and (v) gene expression using microarray studies.

Results : In YMBI group IOP changed from (OD/OS) 18.8 ± 2.34/19 ± 1.63 to 12.7 ± 1.94/13.1±2.23 mmHg, GQL score from 61.6 ± 5.9 to 36.13 ± 7.5, WHO-BREF score from 25±6.5 to 82.8±4.3, cortisol from 497.3 ± 33.85 to 392.3 ± 55.02 ng/ml, β-endorphins from 38.4 ± 2.42 to 52.7 ± 6.19 pg/ml, IL6 from 2.8 ± 0.56 to 1.5 ± 0.6 ng/ml, TNF-α from 57.08 ± 4.38 to 45.36 ± 7.46 pg/ml, BDNF from 56.1 ± 7.87 to 83.9 ± 12.87 ng/ml, ROS from 1625.2 ± 241.32 to 987.8 ± 160.21 RLU/min/104 neutrophil and TAC from 5.9 ± 1.52 to 9.3 ± 1.4 (all p-values < 0.001 except QOL < 0.05). Microarray studies revealed that 54 genes (e.g. NGFR, TAZ, BNP, IL2, IL4, FGFR1, Metallothionein-I) were upregulated and 56 downregulated (e.g. Neuregulin1, NFKBIA, RAR, CYP26A1, Bim, I-kB, EGFR, ERK7) post YMBI (p<0.01) positively impacting uveoscleral outflow, trabecular meshwork maintenance, synapse maturation, anti-inflammatory and anti-apoptotic mpathways. There was no significant improvement in any of these parameters in the control group (all p > 0.05).

Conclusions : A 3 week YMBI in POAG was associated with reduction in IOP, inflammatory markers and ROS; an increase in neurotrohins and endorphins along with an improvement in QOL, with corresponding changes in gene expression pattern. YMBI may be a useful adjunct in the treatment of glaucoma patients.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

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