September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Mixed Platelet-Rich Plasma Eye Drops for the Treatment of Persistent Corneal Epithelial Defects
Author Affiliations & Notes
  • Sahar Balagholi
    Ocular Tissue Engineering Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran (the Islamic Republic of)
    Department of Hematology, School of Allied Medicine, Tehran University of Medical Sciences, Tehran, Iran (the Islamic Republic of)
  • Behnam Ranjbar
    Department of Hematology, School of Allied Medicine, Tehran University of Medical Sciences, Tehran, Iran (the Islamic Republic of)
  • Siamak Delfazaye Baher
    Ophthalmic Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran (the Islamic Republic of)
  • Alireza Baradaran-Rafiei
    Ocular Tissue Engineering Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran (the Islamic Republic of)
  • Mozhgan Rezaeikanavi
    Ocular Tissue Engineering Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran (the Islamic Republic of)
  • Shaban Alizadeh
    Department of Hematology, School of Allied Medicine, Tehran University of Medical Sciences, Tehran, Iran (the Islamic Republic of)
  • Footnotes
    Commercial Relationships   Sahar Balagholi, None; Behnam Ranjbar, None; Siamak Delfazaye Baher, None; Alireza Baradaran-Rafiei, None; Mozhgan Rezaeikanavi, None; Shaban Alizadeh, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 4354. doi:
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      Sahar Balagholi, Behnam Ranjbar, Siamak Delfazaye Baher, Alireza Baradaran-Rafiei, Mozhgan Rezaeikanavi, Shaban Alizadeh; Mixed Platelet-Rich Plasma Eye Drops for the Treatment of Persistent Corneal Epithelial Defects. Invest. Ophthalmol. Vis. Sci. 2016;57(12):4354.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To investigate the effects of mixed platelet-rich plasma (mix PRP) eye drop on the healing of persistent corneal epithelial defects.

Methods : Mixed PRP eye drops were prepared with a specific ratio of autologous platelet-rich plasma and cryoprecipitate, aliquoted to sterile multidose vials. Fifty patients with persistent corneal epithelial defects were treated with mix PRP eye drops four times a day. The patients were categorized into post-surgical, post-transplantation, dry eyes, chemical burns and miscellaneous subgroups. Slitlamp biomicroscopic examinations together with photoslit photography were performed at the baseline and weekly until complete healing. Mean duration of treatment between subgroups was analyzed by ANOVA test. Moreover, mean duration of corneal defect before and after initiation of the treatment was compared by paired t-test.

Results : Mean duration of treatment in the post-surgical subgroup (2.5 ± 1.8 wk) was not significantly different from the post-transplantation (3.2 ± 2.3 wk), dry eyes (2.0 ± 0.0 wk), chemical burns (2.1 ± 0.8 wk), and miscellaneous (1.8 ± 1.2 wk) subgroups. Mean duration of corneal defect after initiation of treatment (2.65 ± 1.84 w) was significantly less than what before the treatment (5.35 ± 1.06 wk) (P value < 0.001); i.e. mixed PRP eye drops led to rapid healing of persistent corneal epithelial defects in all subgroups.

Conclusions : Treatment with autologous mixed PRP eye drops seems to be an effective and reliable approach that accelerates epithelial would healing in cases with persistent corneal epithelial defects of various etiologies.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

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