September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Retinal venous pulsation pressure (RVP) and ocular perfusion pressure (OPP) in patients with retinal vascular occlusion compared to healthy controls
Author Affiliations & Notes
  • Evelyn Voigt
    Department of Ophthalmology, Univ. Hospital Carl Gustav Carus, TU Dresden, Germany, Dresden, Germany
  • Karin R Pillunat
    Department of Ophthalmology, Univ. Hospital Carl Gustav Carus, TU Dresden, Germany, Dresden, Germany
  • Sylvana Ventzke
    Department of Ophthalmology, Univ. Hospital Carl Gustav Carus, TU Dresden, Germany, Dresden, Germany
  • Eberhard Spoerl
    Department of Ophthalmology, Univ. Hospital Carl Gustav Carus, TU Dresden, Germany, Dresden, Germany
  • Lutz E Pillunat
    Department of Ophthalmology, Univ. Hospital Carl Gustav Carus, TU Dresden, Germany, Dresden, Germany
  • Footnotes
    Commercial Relationships   Evelyn Voigt, None; Karin Pillunat, None; Sylvana Ventzke, None; Eberhard Spoerl, None; Lutz Pillunat, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 4625. doi:
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      Evelyn Voigt, Karin R Pillunat, Sylvana Ventzke, Eberhard Spoerl, Lutz E Pillunat; Retinal venous pulsation pressure (RVP) and ocular perfusion pressure (OPP) in patients with retinal vascular occlusion compared to healthy controls. Invest. Ophthalmol. Vis. Sci. 2016;57(12):4625.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To determine RVP and OPP in patients with retinal vascular occlusion in one eye in comparison to non-affected fellow-eye and healthy controls.

Methods : RVP was measured in both eyes of 40 patients (20 ♂, 20 ♀, age 66±15 years) with retinal vascular occlusion on one side (CRAO, BRAO, CRVO, BRVO each 10x) and compared to 27 healthy controls (age 68±10,5). To estimate the pressure in the central retinal vein a Goldmann contact lens associated ophthalmodynamometric device was used (CLD; Meditron GmbH, Voelklingen, Germany). OPP was calculated as OPP 1= 2/3 MAP-IOP (MAP systemic mean arterial pressure) assuming that IOP equals RVP and as OPP 2 = 2/3 MAP–RVP. Data were analyzed with a two-factor repeated measures analysis of variance (ANOVA) with groups and occlusion as the two factors.

Results : In both, occlusion and non-affected fellow eye, IOP was normotensive (11.6±2.8mmHg vs. 12±1.9mmHg). Occlusion and non-affected fellow eye both had statistically significantly higher RVP than healthy controls (occlusion vs. healthy control 42.1±23.1mmHg vs. 11.8±3,8mmHg P=0.001; non-affected fellow-eye vs. healthy control: 33.4±18.2 vs. 11.8±3.6 mmHg P=0.001). Furthermore RVP in occlusion eyes was higher (42.1±23.1mmHg) than in the non-affected fellow-eyes (33.4±18.2mmHg), P=0.008. There was no markedly difference in RVP in the different occlusion types. OPP2 was higher in non-affected fellow eyes than in occlusion eyes (37.2±20.2mmHg vs. 28.5±25.5mmHg, P=0.009) whereas OPP1 differed only slightly (occlusion eyes 59.35±10.25mmHg vs. non-affected fellow-eyes 59±10.4mmHg, P=0.25)

Conclusions : In patients with retinal vascular occlusion RVP is markedly higher in the occlusion as well as in the non-affected fellow eye compared to healthy subjects. Interestingly, a higher RVP could be found in venous as well as arterial occlusions. The mechanism leading to RVP-increase in arterial occlusions is not completely understood. Reasons might be similar atherosclerotic changes at level of lamina cribrosa or a local dysregulation of the retinal veins. Raised RVP causes a reduction of OPP and thus a reduced blood flow to the retina and optic nerve head which may contribute to the development of RVO. If a raised RVP is a risk factor for the development of retinal vascular occlusions, non-affected fellow eyes would be at higher risk, too.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

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