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Anne Sikorav, David Martiano, Alexandra Miere, Oudy Semoun, Giuseppe Querques, Eric H Souied; Optical Coherence Tomographic Angiography features in high myopic choroidal neovascularization. Invest. Ophthalmol. Vis. Sci. 2016;57(12):4646.
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© ARVO (1962-2015); The Authors (2016-present)
To report the ability of optical coherence tomography angiography (OCT-A) to detect the presence of myopic choroidal neovascularization (CNV) and to describe the morphological features of myopic (CNV) on OCT-A
We analyzed consecutive patients affected with CNV secondary to high myopia (>6 Diopters (D) and <26mm of axial length (AL)). All patients underwent a complete ophthalmic examination, including best-corrected visual acuity (BCVA), fluorescein angiography (FA) and spectral domain optical coherent tomography (SD-OCT; Heidelberg Engineering, Heidelberg; Germany). Two masked observers evaluated FA and SD-OCT imaging to ascertain the presence and the degree of activity of myopic CNV. Two others observers evaluated OCT-A images to identify the presence of CNV and to describe the features of the lesion. OCT-A was performed using the RTVue XR Avanti (Optovue Inc). We proposed three types of myopic CNV features on the basis of OCT-Angiography characteristics: “sea fan” characterized by a dense vascular network, “loop” characterized by a rarified linear vascular network, and “interlacing vessels” characterized by a tortuous network with many hyperdense vascular ramifications, without significant dead space.
We enrolled 35 myopic eyes of 27 patients. Median age was 60 years-old, (range 35-71). Median refractive error was –14D (range –6.5 to –22) and median AL was 28.7mm (range 26.3 to 35.1). Combination of FA plus SD-OCT revealed presence of CNV for all included eyes, and CNV were classified as active lesions in 19/35 eyes. OCT-A allowed to visualize the presence of CNV in 23/35 (66%) eyes. Finally, 4 myopic CNV lesions were classified as “sea fan”, 1 was classified as “loop”, 11 were classified as “interlacing”, and 8 myopic CNV showed associated forms.
OCT-A is a non-invasive imaging modality allowing the visualization of CNV in highly myopic eyes in two third of cases. OCT-A does not appear to be sufficient alone to diagnose CNV complicating high myopia and at this time should be considered actually in combination with SD-OCT and conventional angiography
This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.
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