September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Correlations Between Choroidal Thickness and Carotid Artery Doppler Variables in Diabetic Patients Without Diabetic Retinopathy
Author Affiliations & Notes
  • Joana Sofia Cardigos
    Ophthalmology, Lisbon Central Hospital, Lisboa , Portugal
  • Jaime Pamplona
    Neuro-radiology, Lisbon Central Hospital, Lisboa, Portugal
  • Lívio Costa
    Ophthalmology, Lisbon Central Hospital, Lisboa , Portugal
  • Rita Proença
    Ophthalmology, Lisbon Central Hospital, Lisboa , Portugal
    Faculty of Medicina of Lisbon University, Lisboa, Portugal
  • Andre Vicente
    Ophthalmology, Lisbon Central Hospital, Lisboa , Portugal
    Faculty of Medicina of Lisbon University, Lisboa, Portugal
  • Nuno Marques
    Ophthalmology, Lisbon Central Hospital, Lisboa , Portugal
  • João Paulo Cunha
    Ophthalmology, Lisbon Central Hospital, Lisboa , Portugal
    New Univsersity of Lisbon, Faculty of Medical Sciences, Lisboa, Portugal
  • Luis Abegao Pinto
    Ophthalmology, Northen Lisbon Hospital Center, Lisboa, Portugal
    Pharmacology and Ophthalmology, Faculty of Medicinine of Lisbon Hospital, Lisboa, Portugal
  • Joana Ferreira
    Ophthalmology, Lisbon Central Hospital, Lisboa , Portugal
    New Univsersity of Lisbon, Faculty of Medical Sciences, Lisboa, Portugal
  • Footnotes
    Commercial Relationships   Joana Cardigos, None; Jaime Pamplona, None; Lívio Costa, None; Rita Proença, None; Andre Vicente, None; Nuno Marques, None; João Paulo Cunha, None; Luis Abegao Pinto, None; Joana Ferreira, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 4649. doi:
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      Joana Sofia Cardigos, Jaime Pamplona, Lívio Costa, Rita Proença, Andre Vicente, Nuno Marques, João Paulo Cunha, Luis Abegao Pinto, Joana Ferreira; Correlations Between Choroidal Thickness and Carotid Artery Doppler Variables in Diabetic Patients Without Diabetic Retinopathy. Invest. Ophthalmol. Vis. Sci. 2016;57(12):4649.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Choroid receives nearly 70% of ocular blood flow, being sensitive to vascular changes of Diabetes Mellitus (DM), such as systemic atherosclerosis. A choroidal vasculopathy may play a role in diabetic retinopathy (DR) pathogenesis. Once carotid ultrasound (US) is currently used to the screening of systemic atherosclerosis, we performed a prospective cohort study to correlate choroid thickness (CT) with carotid US in patients with type 2 DM without DR.

Methods : We analyzed 17 eyes and 17 carotid US of 17 diabetic patients without DR (13 females and 4 males; mean age 65.3 ± 10.3 years). The CT was measured with Optical Coherence Tomography using the Enhanced Depth Imaging software (OCT-EDI, Heidelberg Engineering®), at 13 different locations (subfoveal and 3 measurements 500 μm apart in all 4 directions - nasal, temporal, superior and inferior). Common and Internal Carotid Arteries (CCA and ICA, respectively) US were performed and the hemodynamic variables included in the study are the Peak Systolic Velocity (PSV), End-Diastolic Velocity (EDV) and Resistance Index (RI). The anatomic variable in study is the Intima-Media Thickness of CCA (CIMT). Systemic Blood Pressure (SBP) and Ocular Pulse Amplitude (OPA) were assed as well. The variables previously indicated are analyzed using nonparametric tests and Spearman correlations.

Results : Choroidal Thickness at 1500 μm inferior to the fovea correlated negatively with the RI of both ICA and CCA (p = 0.022 and 0.035, r = -0.55 and -0.52, respectively). Choroidal Thickness is not correlated with PSV, EDV, RI and CIMT, neither with SBP and OPA in any of the other sites (p > 0.05). The SBP is positively correlated with PSV and RI of ICA (p = 0.003 and 0.030, r = 0.69 and 0.53, respectively).

Conclusions : The absence of correlation between carotid US and CT in all quarters except in the 1500 μm inferior to the fovea lead us to infer that the diabetic choroidopathy, already identified in previous studies, is a localized microangiopathy. The OCT is a non-invasive tool that may allow the identification of early preclinical manifestations of diabetic eye disease.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

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