September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
A Prospective Longitudinal Study to Investigate Corneal Hysteresis as a Risk Factor for Predicting Development of Glaucoma
Author Affiliations & Notes
  • Feilin Zhu
    Department of Ophthalmology, Shiley Eye Institute, University of California, San Diego, La Jolla, California, United States
  • Alberto Diniz-Filho
    Department of Ophthalmology, Shiley Eye Institute, University of California, San Diego, La Jolla, California, United States
  • Robert N Weinreb
    Department of Ophthalmology, Shiley Eye Institute, University of California, San Diego, La Jolla, California, United States
  • Linda M Zangwill
    Department of Ophthalmology, Shiley Eye Institute, University of California, San Diego, La Jolla, California, United States
  • Felipe A Medeiros
    Department of Ophthalmology, Shiley Eye Institute, University of California, San Diego, La Jolla, California, United States
  • Footnotes
    Commercial Relationships   Feilin Zhu, None; Alberto Diniz-Filho, None; Robert Weinreb, Alcon (C), Allergan (C), Amatek (C), Bausch and Lomb (C), Carl Zeiss Meditec (C), Carl Zeiss Meditec (F), Carl Zeiss Meditec (R), Forsight (C), Genentech (F), Heidelberg Engineering (F), Konan (F), National Eye Institute (F), Neurovision (F), Optovue (F), Quark (F), Reichert (F), Tomey (F), Topcon (C), Topcon (F), Valeant (C); Linda Zangwill, Carl Zeiss Meditech (F), Carl Zeiss Meditech (R), Heidelberg Engineering (F), Optovue (F), Optovue (R), Quark (F), Topcon (F); Felipe Medeiros, Alcon (F), Alcon (R), Allergan (F), Allergan (C), Bausch and Lomb (F), Carl Zeiss Meditec (R), Carl Zeiss Meditec (C), Carl Zeiss Meditec (F), Heidelberg Engineering (F), Merck (F), National Eye Institute (F), Novartis (C), Reichert (F), Reichert (R), Sensimed (F), Topcon (F)
  • Footnotes
    Support  NIH Grants EY021818 and EY025056, and core grant P30EY022589
Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to Subscribers Only
      Sign In or Create an Account ×
    • Get Citation

      Feilin Zhu, Alberto Diniz-Filho, Robert N Weinreb, Linda M Zangwill, Felipe A Medeiros; A Prospective Longitudinal Study to Investigate Corneal Hysteresis as a Risk Factor for Predicting Development of Glaucoma. Invest. Ophthalmol. Vis. Sci. 201657(12):.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose : To investigate the role of corneal hysteresis as a risk factor for development of glaucoma in a prospective longitudinal study.

Methods : This was a prospective observational cohort study involving 287 eyes of 199 patients suspected of having glaucoma followed for an average of 3.9 ± 1.8 years. All eyes had normal standard automated perimetry (SAP) visual fields at baseline. Progression to glaucoma was defined as development of 3 consecutive abnormal SAP visual fields during follow-up based on PSD<5% or GHT outside normal limits. Measurements of corneal hysteresis (CH) were acquired at baseline using the Ocular Response Analyzer (ORA, Reichert, Inc.). Univariable and multivariable cox regression models were used to investigate baseline factors associated with development of visual field loss over time.

Results : Fifty-four (19%) of the 287 eyes developed repeatable visual field defects during follow-up. CH measurements at baseline were significant lower in patients who developed glaucoma versus those who did not (9.5 ± 1.5 vs. 10.2 ± 2.0mmHg; P=0.012). Each 1mmHg lower CH was associated with an increase of 22% in the risk of developing glaucoma during follow-up (HR=1.22; 95% CI: 1.04 – 1.41; P=0.013). In a multivariable model adjusting for age, intraocular pressure, corneal thickness and pattern standard deviation, CH was still predictive of development of glaucoma (HR = 1.20; 95% CI: 1.01 – 1.42; P=0.039).

Conclusions : In a prospective longitudinal study, lower CH measurements were significantly associated with increased risk of developing glaucoma over time.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×