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Feilin Zhu, Alberto Diniz-Filho, Robert N Weinreb, Linda M Zangwill, Felipe A Medeiros; A Prospective Longitudinal Study to Investigate Corneal Hysteresis as a Risk Factor for Predicting Development of Glaucoma. Invest. Ophthalmol. Vis. Sci. 201657(12):.
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© 2017 Association for Research in Vision and Ophthalmology.
To investigate the role of corneal hysteresis as a risk factor for development of glaucoma in a prospective longitudinal study.
This was a prospective observational cohort study involving 287 eyes of 199 patients suspected of having glaucoma followed for an average of 3.9 ± 1.8 years. All eyes had normal standard automated perimetry (SAP) visual fields at baseline. Progression to glaucoma was defined as development of 3 consecutive abnormal SAP visual fields during follow-up based on PSD<5% or GHT outside normal limits. Measurements of corneal hysteresis (CH) were acquired at baseline using the Ocular Response Analyzer (ORA, Reichert, Inc.). Univariable and multivariable cox regression models were used to investigate baseline factors associated with development of visual field loss over time.
Fifty-four (19%) of the 287 eyes developed repeatable visual field defects during follow-up. CH measurements at baseline were significant lower in patients who developed glaucoma versus those who did not (9.5 ± 1.5 vs. 10.2 ± 2.0mmHg; P=0.012). Each 1mmHg lower CH was associated with an increase of 22% in the risk of developing glaucoma during follow-up (HR=1.22; 95% CI: 1.04 – 1.41; P=0.013). In a multivariable model adjusting for age, intraocular pressure, corneal thickness and pattern standard deviation, CH was still predictive of development of glaucoma (HR = 1.20; 95% CI: 1.01 – 1.42; P=0.039).
In a prospective longitudinal study, lower CH measurements were significantly associated with increased risk of developing glaucoma over time.
This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.
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