September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Prospective, Multicenter Investigation of Aflibercept Treat and Extend Therapy for Neovascular Age-related Macular Degeneration (ATLAS Study): One and Two Year Results
Author Affiliations & Notes
  • Francis Char DeCroos
    Southeastern Retina Associates, Chattanooga, Tennessee, United States
    Retina Service, Wills Eye Institute, Philadelphia, Pennsylvania, United States
  • David Carleton Reed
    Retina Service, Wills Eye Institute, Philadelphia, Pennsylvania, United States
  • Murtaza K Adam
    Retina Service, Wills Eye Institute, Philadelphia, Pennsylvania, United States
  • David A Salz
    Retina Service, Wills Eye Institute, Philadelphia, Pennsylvania, United States
  • Omesh Gupta
    Retina Service, Wills Eye Institute, Philadelphia, Pennsylvania, United States
  • Allen C Ho
    Retina Service, Wills Eye Institute, Philadelphia, Pennsylvania, United States
  • Carl D Regillo
    Retina Service, Wills Eye Institute, Philadelphia, Pennsylvania, United States
  • Footnotes
    Commercial Relationships   Francis DeCroos, Regeneron (F); David Reed, Regeneron (F); Murtaza Adam, Regeneron (F); David Salz, Regeneron (F); Omesh Gupta, Regeneron (F); Allen Ho, Regeneron (F); Carl Regillo, Acucela (F), Acucela (C), Alcon (F), Alcon (C), Allergan (F), Allergan (C), Genentech (F), Genentech (C), GSK (F), Ocata (F), Ophthotech (F), Regeneron (F), Regeneron (C)
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:
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      Francis Char DeCroos, David Carleton Reed, Murtaza K Adam, David A Salz, Omesh Gupta, Allen C Ho, Carl D Regillo; Prospective, Multicenter Investigation of Aflibercept Treat and Extend Therapy for Neovascular Age-related Macular Degeneration (ATLAS Study): One and Two Year Results. Invest. Ophthalmol. Vis. Sci. 201657(12):.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To determine the visual outcomes, anatomic outcomes, and the number of injections required when using a treat and extend regimen with aflibercept for neovascular age-related macular degeneration (NVAMD).

Methods : Forty eyes of forty participants met inclusion criteria for this multicenter, prospective, open label study. These eyes were treated every 4 weeks until no signs of macular exudation by clinical assessment including spectral domain optical coherence tomography. The treatment intervals were then extended by 2 weeks until either an exudative recurrence or a treatment interval of 16 weeks was achieved. Main outcome measures included change from baseline visual acuity, change in central retinal thickness (CRT), mean number of annual injections, treatment interval, and adverse events. Wilcoxon signed rank test was used for analysis.

Results : Forty eyes of forty patients were enrolled. An average of 8.0 treatments resulted in a median best corrected visual acuity (BCVA) improvement of 11 letters (p < 0.001) and CRT decrease of 163 micrometers (p < 0.001) during the first year. An average of 5.9 treatments resulted in a sustained median BCVA improvement of 11 letters (p < 0.001) and CRT decrease of 161 micrometers (p < 0.001) during the second year. A treatment interval of eight weeks or longer was obtained in 71% and 82% of patients at one and two years respectively. A treatment interval of twelve weeks or longer was obtained in 35% and 41% of patients at one and two years respectively. No ocular or related systemic adverse events were observed.

Conclusions : Aflibercept treat and extend therapy for NVAMD led to visual and anatomic improvement at year 1, and these gains were sustained at year 2 with a decreased treatment burden relative to year 1. A sustained treatment interval of twelve weeks or longer was achieved in more than a third of patients.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

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