September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Smoking is a risk factor for proliferative vitreoretinopathy after traumatic retinal detachment
Author Affiliations & Notes
  • Tomasz Stryjewski
    Ophthalmology, MEEI, Boston, Massachusetts, United States
  • Michael Andreoli
    Illinois Eye and Ear Infirmary, Chicago, Illinois, United States
  • Christopher Andreoli
    Ophthalmology, MEEI, Boston, Massachusetts, United States
  • Dean Eliott
    Ophthalmology, MEEI, Boston, Massachusetts, United States
  • Footnotes
    Commercial Relationships   Tomasz Stryjewski, None; Michael Andreoli, None; Christopher Andreoli, None; Dean Eliott, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:
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    • Get Citation

      Tomasz Stryjewski, Michael Andreoli, Christopher Andreoli, Dean Eliott; Smoking is a risk factor for proliferative vitreoretinopathy after traumatic retinal detachment. Invest. Ophthalmol. Vis. Sci. 201657(12):.

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      © 2017 Association for Research in Vision and Ophthalmology.

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Abstract

Purpose : To determine the incidence of retinal redetachment due to proliferative vitreoretinopathy (PVR) after open globe trauma in smokers and non-smokers.

Methods : A retrospective review of 892 patients comprising 893 open globe injuries presenting to the Massachusetts Eye and Ear Infirmary (MEEI) between 1999 and 2011 was undertaken. Retinal detachment (RD) was diagnosed in 255 eyes and 138 underwent successful surgical repair. Time to redetachment was calculated using the Kaplan-Meier method and risk factors were determined using Cox proportional hazards modeling.

Results : Within one year after retinal detachment surgery, 47% (95% CI, 39%-56%) of all 138 repaired retinas redetached due to PVR. Being a smoker was associated with a higher rate of failure (adjusted Hazard Ratio (HR) 1.96 p=0.01). As shown in prior studies, the presence of PVR at the time of surgery was also an independent risk factor for failure (adjusted HR 2.13, p=0.005). Treatment with vitrectomy-buckle compared favorably to vitrectomy alone (adjusted HR 0.58, p=0.04). Only 8% of eyes that redetached achieved a best corrected visual acuity of 20/200 or better, in comparison to 44% of eyes that did not redetach (p<0.001).

Conclusions : Proliferative vitreoretinopathy is a common complication after the repair of retinal detachment associated with open globe trauma, and being a smoker is a risk factor for redetachment. Further study is needed to understand the pathophysiologic mechanisms underlying this correlation.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

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