September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Optical Coherence Tomography Angiography quantifying choroidal blood flow change of Idiopathic Macular Hole before and after surgery
Author Affiliations & Notes
  • Yufei Teng
    Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing, Beijing, China
    Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China
  • Wu Liu
    Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China
  • Footnotes
    Commercial Relationships   Yufei Teng, None; Wu Liu, None
  • Footnotes
    Support  none
Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:
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      Yufei Teng, Wu Liu; Optical Coherence Tomography Angiography quantifying choroidal blood flow change of Idiopathic Macular Hole before and after surgery. Invest. Ophthalmol. Vis. Sci. 201657(12):.

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      © 2017 Association for Research in Vision and Ophthalmology.

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Abstract

Purpose : The alteration of parafoveolar choroidal blood circulation in idiopathic macular hole remians unclear. In this study we use Angio Optical Coherence Tomography (OCTA) to compare the parafoveolar choroidal blood flow in both eyes of idiopathic macular hole patients with normal healthy controls. The parafoveolar choroidal blood flow change of eyes with idiopathic macular hole before and after vitrectomy was also determined.

Methods : 25 patients (23 females, 2 males) with idiopathic macular hole (IMH) who performed vitrectomy were recruited; 30 age-and sex-matched healthy controls were enrolled. OCTA was used to measure parafoveolar choroidal blood flow to obtain three measurements: flow area, parafovea vessel density and parafovea vessel index. Examinations were performed in one day before surgery and one month after surgery.

Results : Flow area, parafovea vessel density and index in parafoveolar choroid were significantly lower in the eyes with idiopathic macular hole than unaffected fellow eyes and healthy control eyes (p<0.001, repeated measures analysis of variance). No difference was found between unaffected fellow group and healthy control group. One month after vitrectomy, choroidal flow area, parafovea vessel density and vessel index of IMH eyes were significantly increased with the comparison of per-operation (p<0.001, Wilcoxon signed-rank). Basal diameter of macular hole was negatively correlated with flow area and parafovea vessel density/index in IMH group (p<0.001, Linear regression).

Conclusions : By using OCTA, we revealed that flow area, parafovea vessel density and index in choroid were reduced in the eyes with idiopathic macular hole; and choroidal blood flow was negatively correlated with macular hole basal diameter. Our finding suggested that parafoveolar choroid blood flow might be directly affected by the structure of fovea. The reversible reduction of choroid blood flow might be a result of idiopathic macular hole formation.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

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