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Thomas William White; Differences in second messenger permeability of lens connexins. Invest. Ophthalmol. Vis. Sci. 201657(12):.
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© ARVO (1962-2015); The Authors (2016-present)
Presentation Description :
Intercellular channels assembled from different connexin proteins have unique molecular permeability. Gap junctions have been historically described as relatively non-selective, permeable to a wide variety of molecules with a size smaller than ~1200 Daltons. However, experiments carefully examining the movement of ions and dyes between cells expressing different connexins have revealed that there are connexin-dependent differences in permeation. We have extended this type of analysis to the signaling molecules cAMP, IP3 and Ca2+. Most cell types express more than one connexin, and the permeability data suggest that loss of a single connexin species within a given eye tissue (i.e. by genetic mutation or gene knockout) not only changes the macroscopic levels of communication, but also significantly alters the range of molecules being exchanged between the coupled cells.
This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.
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