September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Longitudinal impact of changes in visual acuity on vision-specific function
Author Affiliations & Notes
  • Eva K Fenwick
    Singapore Eye Research Institute, Singapore, Singapore
    Centre for Eye Research Australia, University of Melbourne, Melbourne, Victoria, Australia
  • Peng Guan Ong
    Singapore Eye Research Institute, Singapore, Singapore
  • Ryan EK Man
    Singapore Eye Research Institute, Singapore, Singapore
  • Charumathi Sabanayagam
    Singapore Eye Research Institute, Singapore, Singapore
    Duke-NUS Graduate Medical School, Singapore, Singapore
  • Ching-Yu Cheng
    Singapore Eye Research Institute, Singapore, Singapore
    Duke-NUS Graduate Medical School, Singapore, Singapore
  • Tien Yin Wong
    Singapore Eye Research Institute, Singapore, Singapore
    Duke-NUS Graduate Medical School, Singapore, Singapore
  • Preeti Gupta
    Singapore Eye Research Institute, Singapore, Singapore
  • Ecosse Luc Lamoureux
    Singapore Eye Research Institute, Singapore, Singapore
    Duke-NUS Graduate Medical School, Singapore, Singapore
  • Footnotes
    Commercial Relationships   Eva Fenwick, None; Peng Guan Ong, None; Ryan Man, None; Charumathi Sabanayagam, None; Ching-Yu Cheng, None; Tien Wong, None; Preeti Gupta, None; Ecosse Lamoureux, None
  • Footnotes
    Support  Dr Eva Fenwick is funded by a National Health and Medical Research Council (NHMRC) Early Career Fellowship (#1072987). The Singapore Epidemiology of Eye Disease study was supported by the National Medical Research Council (STaR/0003/2008), the Singapore Bio Imaging Consortium (C-011/2006) and the Biomedical Research Council (08/1/35/19/550).
Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:
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      Eva K Fenwick, Peng Guan Ong, Ryan EK Man, Charumathi Sabanayagam, Ching-Yu Cheng, Tien Yin Wong, Preeti Gupta, Ecosse Luc Lamoureux; Longitudinal impact of changes in visual acuity on vision-specific function. Invest. Ophthalmol. Vis. Sci. 201657(12):.

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      © 2017 Association for Research in Vision and Ophthalmology.

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Abstract

Purpose : There are limited data on the longitudinal association between visual acuity (VA) and vision-specific function (VF), especially in Asia. We examined the association in a population-based cohort of Singapore Malays.

Methods : 1895 adults (862 (45.5%) males, aged 40-86 years) from the Singapore Malay Eye Study had clinical and VF data (VF-11 scale) at baseline (2004-06) and follow-up (2010-13). Best-corrected VA was measured using a LogMAR chart. Baseline and follow-up data of the VF-11 were validated using Rasch analysis and the stacking method. Mean differences and effect sizes (ES) for the composite VF-11 score and individual items were calculated for 3 categories of better eye VA change over the follow-up period (VA improved ≥2 lines; no change [-2<VA<2]; VA loss ≥2 lines). The VA loss group was stratified by incident vision impairment (VI) (baseline: VA ≥6/12 and follow-up: <6/12) and VI progression (VI worsening by ≥2 lines over time). The associations between VA and VF changes were assessed using multivariate linear regression models, with VA change analyzed continuously (per 2 line decrease) and categorically.

Results : At follow-up, 405 (21.4%) participants had lost ≥2 lines of VA (mean VA loss 0.28 LogMAR, p<0.001), which was associated with a mean -0.81±2.07SD logit reduction in VF (moderate ES: -0.58). Greatest VF changes were for seeing stairs, watching TV and cooking (-0.95, -0.94 and -0.92 logit, respectively). Of the 405 subjects, 124 (30.6%) had incident VI and 281 (69.4%) had VI progression, which were associated with -1.44±2.43 (ES -0.96) and -0.63±1.82 (ES -0.40) logit reductions in VF, respectively. Participants with a ≥2 line gain in VA (n=31, 1.6%) and no VA change (n=1459, 77.0%) also had significant mean VF declines of -0.46±2.45 and -0.30±1.88 logits, although ES were small (-0.23). In adjusted multivariate models, a -0.31 (CI [confidence interval] -0.42, -0.21, p<0.01) logit reduction in VF was associated with a 2 line decrease in VA. Compared to those with no VA change, those with ≥2 line VA loss had 66% loss of VF (β=-0.22 CI -0.43, -0.02).

Conclusions : One in five adult Malays lost ≥2 lines of VA over 6 years resulting in a sizable deterioration in ability to perform vision-specific tasks. Loss of VF was markedly greater in those who developed VI compared to those whose VI worsened. Strategies to prevent and delay the progression of VI are warranted.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

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