September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Inflammatory markers in the SMILE lenticule and its impact on corneal healing
Author Affiliations & Notes
  • CAROLINA ELIZABETH MOLINA RÍOS
    CORNEA AND REFRACTIVE SURGERY, HOSPITAL NUESTRA SEÑORA DE LA LUZ, DF, DISTRITO FEDERAL, Mexico
  • ELISA ALEGRIA GOMEZ
    CORNEA AND REFRACTIVE SURGERY, HOSPITAL NUESTRA SEÑORA DE LA LUZ, DF, DISTRITO FEDERAL, Mexico
  • Oscar Fernandez
    CORNEA AND REFRACTIVE SURGERY, HOSPITAL NUESTRA SEÑORA DE LA LUZ, DF, DISTRITO FEDERAL, Mexico
  • Footnotes
    Commercial Relationships   CAROLINA MOLINA RÍOS, None; ELISA ALEGRIA GOMEZ, None; Oscar Fernandez, None
  • Footnotes
    Support  none
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 4862. doi:
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      CAROLINA ELIZABETH MOLINA RÍOS, ELISA ALEGRIA GOMEZ, Oscar Fernandez; Inflammatory markers in the SMILE lenticule and its impact on corneal healing. Invest. Ophthalmol. Vis. Sci. 2016;57(12):4862.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To describe the inflammatory markers in the lenticule of corneal SMILE related inflammatory process in patients undergoing refractive surgery.

Methods : Prospective, transversal, observational and descriptive study in patients undergoing refractive surgery (SMILE) who meet the inclusion criteria. All the extracted lenticules underwent determination of inflammatory cytokines and these results were correlated with visual acuity and spherical equivalent pre and postoperative data with flap and residual stromal lenticule.

Results : 36 patients (43 eyes) were analyzed. The average age for men of 28 ± 6 years and women 29 ± 7 years. IL8 cytokines obtained were 1.1 ± 1.3pg / ml and 1.3 ± TNF alfa 1.3pg / ml, 0.5 ± 0.5pg IL12 / ml and 0.3 ± IL1b 1.3pg / ml. The suction flap and lenticule do not have significant correlation with cytokine levels, however the minimum thickness 16.0 ± 4.0μm correlated negatively with TNF alfa (p = 0.034) and IL-12 (p = 0.017).

Conclusions : IL8 interleukins, TNF alfa, IL12 and IL1b are released in response to stromal and epithelial injury, even without being given their impact on refractive outcomes, establishing the need for future studies.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

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