September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Silent Type 1 Choroidal Neovascular Membrane in Age-Related Macular Degeneration Detected by Optical Coherence Tomography Angiography
Author Affiliations & Notes
  • Brian Tieu
    R&D, UNIVERSITY OF MISSISSIPPI MEDICAL CENTER, Jackson, Mississippi, United States
  • Matt Olsen
    R&D, UNIVERSITY OF MISSISSIPPI MEDICAL CENTER, Jackson, Mississippi, United States
  • Jordan Burnham
    R&D, UNIVERSITY OF MISSISSIPPI MEDICAL CENTER, Jackson, Mississippi, United States
  • Ching Jygh Chen
    R&D, UNIVERSITY OF MISSISSIPPI MEDICAL CENTER, Jackson, Mississippi, United States
  • Footnotes
    Commercial Relationships   Brian Tieu, None; Matt Olsen, None; Jordan Burnham, None; Ching Chen, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 4938. doi:
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    • Get Citation

      Brian Tieu, Matt Olsen, Jordan Burnham, Ching Jygh Chen; Silent Type 1 Choroidal Neovascular Membrane in Age-Related Macular Degeneration Detected by Optical Coherence Tomography Angiography. Invest. Ophthalmol. Vis. Sci. 2016;57(12):4938.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To report silent type 1 choroidal neovascular membrane (CNV) in Age-Related Macular Degeneration (ARMD) as detected by optical coherence tomography angiography (OCTA)

Methods : Retrospective review of Split Spectrum Amplitude Decorrelation Angiography based OCTA, SD-OCT and fluorescein angiography (FA) results on patients with silent type 1 CNV in ARMD.

Results : Eight eyes with wet ARMD were clinically quiet. FA showed no definite fluorescein leakage or increased fluorescein staining in the late phase. One eye showed a small retinal pigment epithelial detachment. SD-OCT showed no definitive intra- or sub-retinal fluid. However, OCTA detected blood flow in type I CNV in each eye. The size and vascular volume of the CNV varied. The contralateral eyes showed active type 1 CNV in 4, type 2 CNV in 1, treated and quiescent type 1 CNV in 1, and no CNV in 2. No silent CNV became active in follow-up examinations for over one year.

Conclusions : OCTA successfully detected subclinical, silent CNVs in 8 ARMD patients. Although it is uncertain when and whether the silent CNVs will become active, detection of these subclinical CNVs by OCTA may prompt a more vigilant follow-up for these patients.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

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