September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Swept Source Optical Coherence Tomography Angiography of Asymptomatic Neovascularization in Intermediate Age-Related Macular Degeneration
Author Affiliations & Notes
  • Luiz Roisman
    Ophthalmology, Bascom Palmer Eye Institute, MIAMI, Florida, United States
    Ophthalmology, Universidade federal de Sao Paulo, Sao Paulo, Brazil
  • Qinqin Zhang
    university of washington, SEATTLE, Washington, United States
  • Ruikang K Wang
    university of washington, SEATTLE, Washington, United States
  • Giovanni Gregori
    Ophthalmology, Bascom Palmer Eye Institute, MIAMI, Florida, United States
  • Anqi Zhang
    university of washington, SEATTLE, Washington, United States
  • Chieh-LI Chen
    university of washington, SEATTLE, Washington, United States
  • Lin An
    zeiss meditec, DUBLIN, California, United States
  • gillian robbins
    Ophthalmology, Bascom Palmer Eye Institute, MIAMI, Florida, United States
  • ANDREW MILLER
    Ophthalmology, Bascom Palmer Eye Institute, MIAMI, Florida, United States
  • FANG ZHENG
    Ophthalmology, Bascom Palmer Eye Institute, MIAMI, Florida, United States
  • Philip J Rosenfeld
    Ophthalmology, Bascom Palmer Eye Institute, MIAMI, Florida, United States
  • Footnotes
    Commercial Relationships   Luiz Roisman, Carl Zeiss (R); Qinqin Zhang, None; Ruikang Wang, None; Giovanni Gregori, ZEISS MEDITEC (R); Anqi Zhang, None; Chieh-LI Chen, None; Lin An, ZEISS MEDITEC (E); gillian robbins, ZEISS MEDITEC (R); ANDREW MILLER, ZEISS MEDITEC (R); FANG ZHENG, ZEISS MEDITEC (R); Philip Rosenfeld, ZEISS MEDITEC (R)
  • Footnotes
    Support  Carl Zeiss Travel Funding
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 4939. doi:
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      Luiz Roisman, Qinqin Zhang, Ruikang K Wang, Giovanni Gregori, Anqi Zhang, Chieh-LI Chen, Lin An, gillian robbins, ANDREW MILLER, FANG ZHENG, Philip J Rosenfeld; Swept Source Optical Coherence Tomography Angiography of Asymptomatic Neovascularization in Intermediate Age-Related Macular Degeneration. Invest. Ophthalmol. Vis. Sci. 2016;57(12):4939.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Purpose: To identify subclinical type 1 neovascularization in asymptomatic eyes with intermediate age-related macular degeneration (iAMD) using swept source optical coherence tomography angiography (SS-OCTA)

Methods : Methods: Consecutive patients with asymptomatic iAMD in one eye and neovascular AMD in their fellow eye were enrolled in a prospective OCT study at the Bascom Palmer Eye Institute. They underwent SS-OCTA, fluorescein angiography (FA), and indocyanine green angiography (ICGA). Images from these three angiographic techniques were then compared. Additional patients with intermediate age-related macular degeneration (iAMD) were imaged as well.

Results : Results: Eleven consecutive patients with iAMD in one eye and neovascular AMD in their fellow eye were imaged with FA, ICGA, and SS-OCTA between August 2014 and September 2015. Clinical examination of the 11 eyes revealed drusen and pigmentary abnormalities in the central macula and no evidence of macular fluid on routine OCT imaging. Ten of the 11 eyes had no evidence of leakage on FA and one eye had questionable fluorescein leakage. ICGA revealed the presence of central macular plaques in three of the 11 asymptomatic eyes with iAMD, and SS-OCTA was able to unambiguously identify type 1 neovascularization corresponding to the plaques in all three eyes. No additional foci of neovascularization were identified in the remaining eight asymptomatic eyes with iAMD. To determine the true prevalence of type 1 CNV in asymptomatic eyes with iAMD, we have imaged 103 patients with non-exudative AMD in one eye and exudative AMD in their fellow eye. Additional examples of type 1 neovascularization in these asymptomatic eyes with iAMD will be shown.

Conclusions : Conclusions: SS-OMAG identified type 1 neovascularization corresponding to ICGA plaques in asymptomatic eyes with iAMD. The ability of OCTA to provide non-invasive, fast, detailed, depth-resolved identification of non-exudative neovascular lesions in eyes with iAMD suggests the need for a new classification system that distinguishes between neovascular and non-neovascular iAMD.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

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