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Federico Corvi, Eric H Souied, Vittorio Capuano, Eliana Costanzo, Lucia Benatti, Lea Querques, Francesco Bandello, Giuseppe Querques; Choroidal structure in eyes with drusen and reticular pseudodrusen by binarization of optical coherence tomographic images.. Invest. Ophthalmol. Vis. Sci. 2016;57(12):4940.
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© ARVO (1962-2015); The Authors (2016-present)
To compare the luminal and stromal area of the choroid in eyes with drusen and reticular pseudodrusen (RPD) and to investigate their change over 24 months.
Images of optical coherence tomography were converted to binary images. The cross-sectional total choroidal area, luminal area, and stromal area of the choroid were measured in eyes with drusen, RPD, and control subjects at baseline examination and after 24 months.
A total of 18 eyes of 18 subjects for each group (drusen, RPD and control subjects) were included in the study. In eyes with drusen we found reduction of mean total choroidal area (p=0.0005), luminal area (p=0.003) and stromal area (p=0.007) from baseline to month-24; no change of ratio between luminal-stromal area and the choroidal area was recorded (p=0.1 and p=0.1, respectively). Similarly, in eyes with RPD we found reduction of mean total choroidal area (p<0.0001), luminal area (p<0.0001) and stromal area (p=0.0002) from baseline to month-24; no change of ratio between luminal-stromal area and the total choroidal area was recorded (p=0.1 and p=0.1, respectively). Mean luminal, stromal and total choroidal area were reduced in eyes with RPD, as compared to eyes with drusen and controls at both baseline and month-24 (p<0.05 for all). In eyes with RPD the stromal area was more represented, as we found lower mean ratio of luminal and total choroidal area compared with eyes with drusen and controls at both baseline and month-24 (p<0.05 for all).
Mean total choroidal, luminal and stromal area reduce over 24 months in a similar manner in eyes with drusen and RPD (no changes in mean luminal-stromal ratio). Mean choroidal luminal, stromal and area are more reduced in eyes with RPD, as compared to eyes with drusen and controls. The stromal area was more represented in eyes with RPD suggesting a possible role in the pathogenesis and disease progression.
This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.
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