September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Longitudinal analysis of drusen volume in intermediate age-related macular degeneration using different SD-OCT scan patterns
Author Affiliations & Notes
  • Sarah Thiele
    Ophthalmology, University of Bonn, Bonn, Germany
  • Jennifer Nadal
    Institute for Medical Biometry, Informatics and Epidemiology, University of Bonn, Bonn, Germany
  • Rui Hua
    Ophthalmology, University of Bonn, Bonn, Germany
  • Monika Fleckenstein
    Ophthalmology, University of Bonn, Bonn, Germany
  • Matthias Schmid
    Institute for Medical Biometry, Informatics and Epidemiology, University of Bonn, Bonn, Germany
  • Frank G Holz
    Ophthalmology, University of Bonn, Bonn, Germany
  • Steffen Schmitz-Valckenberg
    Ophthalmology, University of Bonn, Bonn, Germany
  • Footnotes
    Commercial Relationships   Sarah Thiele, Carl Zeiss Meditec (F), Heidelberg Engineering (F), Optos (F); Jennifer Nadal, Genentech (F); Rui Hua, None; Monika Fleckenstein, Bayer (R), Carl Zeiss Meditec (F), Genentech (F), Genentech (R), Heidelberg Engineering (F), Heidelberg Engineering (R), Merz (C), Novartis (R), Optos (F), US20140303013 A1 pending (P); Matthias Schmid, None; Frank Holz, Acucela (F), Acucela (C), Alcon (F), Alcon (C), Allergan (F), Allergan (C), Bayer Healthcare (F), Bayer Healthcare (C), Boehringer Ingelheim (C), Carl Zeiss Meditec (F), Genentech (F), Genentech (C), Heidelberg Engineering (F), Heidelberg Engineering (C), Heidelberg Engineering (R), Merz (C), Novartis (F), Novartis (C), Optos (F), Roche (C); Steffen Schmitz-Valckenberg, Alcon (C), Alcon (F), Allergan (F), Bayer (F), Bayer (R), Carl Zeiss Meditec (F), Formycon (F), Genentech (F), Heidelberg Engineering (F), Heidelberg Engineering (R), Novartis (C), Novartis (F), Optos (F), Roche (F)
  • Footnotes
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Investigative Ophthalmology & Visual Science September 2016, Vol.57, 4941. doi:
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      Sarah Thiele, Jennifer Nadal, Rui Hua, Monika Fleckenstein, Matthias Schmid, Frank G Holz, Steffen Schmitz-Valckenberg; Longitudinal analysis of drusen volume in intermediate age-related macular degeneration using different SD-OCT scan patterns. Invest. Ophthalmol. Vis. Sci. 2016;57(12):4941.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Dynamic changes of drusen volume have been discussed as a disease marker in eyes with intermediate age-related macular degeneration (AMD). The aim of this study was to evaluate two different scan patterns of optical coherence tomography (OCT) for the assessment of the natural course of drusen volume over four years in the context of a prospective, longitudinal natural history study.

Methods : Thirty-eight eyes with intermediate AMD of 38 patients (mean age 70 ± 6.1 years, range 51-82 years) that did not show any conversion to late stage AMD in the study eye over 4 years were included in the current analysis. Annual multimodal imaging included acquisition of two different raster scan patterns (field size 20°x15°): A. 19 B-scans (i. e. distance approx. 240 µm) and B. 145 B-scans (30 µm). Automatic segmentation of Bruch’s membrane and the retinal pigment epithelium was manually corrected as indicated in each individual B-scan.

Results : The mean drusen volume at baseline within the five inner subfields of the Early Treatment in Diabetic Retinopathy Study grid was 0.21 ± 0.10 mm3 for scan pattern A and 0.20 ± 0.07 mm3 for scan pattern B. The mean change from baseline was 0.02 ± 0.04 mm3 and -0.001 ± 0.09 mm3 at year 1, 0.05 ± 0.09 mm3 and 0.03 ± 0.11 mm3 at year 2, 0.03 ± 0.08 mm3 and 0.04 ± 0.14 mm3 at year 3 and -0.003 ± 0.10 mm3 and 0.05 ± 0.17 mm3 at year 4, respectively (p>0,05 at all four years). Statistical analysis revealed no significant difference between scan pattern A and B for the assessment of change in drusen volume over time (p = 0.21).

Conclusions : Eyes with intermediate AMD and no conversion to late AMD stages on average show relatively small changes of drusen volume over time. The assessed drusen volume based in 19 vs. 145 B-scans did not differ significantly. Further longitudinal analysis also including eyes with intermediate AMD with conversion to late-AMD are required to further investigate the quantification of drusen over time volume as a marker for disease progression.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

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