September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Reticular pseudodrusen characterization by retromode imaging
Author Affiliations & Notes
  • Daniele De Geronimo
    Ophthalmology, IRCCS-G.B.Bietti Foundation, Rome, Italy
  • Lea Querques
    Ophthalmology, IRCCS San Raffaele Scientific Institute, University Vita-Salute San Raffaele, Milan, Italy
  • Maria Cristina Parravano
    Ophthalmology, IRCCS-G.B.Bietti Foundation, Rome, Italy
  • Antonluca Boninfante
    Ophthalmology, IRCCS-G.B.Bietti Foundation, Rome, Italy
  • Paola Giorno
    Ophthalmology, IRCCS-G.B.Bietti Foundation, Rome, Italy
  • Monica Varano
    Ophthalmology, IRCCS-G.B.Bietti Foundation, Rome, Italy
  • Francesco Bandello
    Ophthalmology, IRCCS San Raffaele Scientific Institute, University Vita-Salute San Raffaele, Milan, Italy
  • Giuseppe Querques
    Ophthalmology, IRCCS San Raffaele Scientific Institute, University Vita-Salute San Raffaele, Milan, Italy
  • Footnotes
    Commercial Relationships   Daniele De Geronimo, None; Lea Querques, None; Maria Cristina Parravano, None; Antonluca Boninfante, None; Paola Giorno, None; Monica Varano, None; Francesco Bandello, None; Giuseppe Querques, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 4959. doi:
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      Daniele De Geronimo, Lea Querques, Maria Cristina Parravano, Antonluca Boninfante, Paola Giorno, Monica Varano, Francesco Bandello, Giuseppe Querques; Reticular pseudodrusen characterization by retromode imaging. Invest. Ophthalmol. Vis. Sci. 2016;57(12):4959.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Reticular pseudodrusen (RPD), associated with age related macular degeneration (AMD), are suggested to be located internal to the retinal pigment epithelium (RPE), in contrast to conventional drusen. Different stages of RPD have been proposed on Spectral Domain-OCT or in color fundus photographs and infrared reflectance (IR). In this report we evaluated the RPD characteristics on the so-called ‘retromode’ imaging, which rely on the detection of scattered light from the fundus, and classified RPD on the basis of the appearance of the deposits in the outer retina.

Methods : Consecutive patients with early AMD with RPD in at least one eye, detected by IR and SD-OCT, but without typical drusen were included. They performed retromode imaging of the fundus with the Nidek F-10 confocal digital ophthalmoscope. We classified the RPD on the basis of the appearance of the deposits on the ‘retromode’ images.

Results : Nine eyes of 7 consecutive patients (5 Female/2 Male; mean age 72.1+/-4.1 years) with early AMD with RPD in at least one eye, but without typical drusen, were included. RPD were identified by means of laterally scattered light of retromode and the deposits have been classified as round, bended and interlacing. In particular, all these different shapes were detected in variable proportions in all eyes when the right aperture was used, and the dark shadows were in the right side.

Conclusions : Our study corroborates SD-OCT demonstration that in RPD the deposits accumulate in the outer retina with variable size and shapes. The coexistence in all eyes of different shapes for the deposits may explain the reticular appearance previously claimed by different authors as an exclusive peculiarity of the choroid.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

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