September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
DYNAMIC FUNCTIONALITY OF RETINAL VESSELS IN EYES WITH CENTRAL SEROUS RETINOPATHY
Author Affiliations & Notes
  • Livia Tomasso
    IRCCS Ospedale San Raffaele, Milano, Italy
  • Lucia Benatti
    IRCCS Ospedale San Raffaele, Milano, Italy
  • Federico Corvi
    IRCCS Ospedale San Raffaele, Milano, Italy
  • Fatemeh Darvizeh
    IRCCS Ospedale San Raffaele, Milano, Italy
  • Giovanni Baldin
    IRCCS Ospedale San Raffaele, Milano, Italy
  • Adriano Carnevali
    IRCCS Ospedale San Raffaele, Milano, Italy
  • Lea Querques
    IRCCS Ospedale San Raffaele, Milano, Italy
  • Ilaria Zucchiatti
    IRCCS Ospedale San Raffaele, Milano, Italy
  • Francesco Bandello
    IRCCS Ospedale San Raffaele, Milano, Italy
  • Giuseppe Querques
    IRCCS Ospedale San Raffaele, Milano, Italy
  • Footnotes
    Commercial Relationships   Livia Tomasso, None; Lucia Benatti, None; Federico Corvi, None; Fatemeh Darvizeh, None; Giovanni Baldin, None; Adriano Carnevali, None; Lea Querques, None; Ilaria Zucchiatti, None; Francesco Bandello, Alcon (C), Alimera Science (C), Allergan (C), Bausch&Lomb (C), Bayer (C), Farmila Thea (C), Genetech (C), Hofmann la Roche (C), Novagali pharma (C), Novartis (C), Sanofi Aventis (C), Thrombogenics (C); Giuseppe Querques, Alimera Science (C), Allergan (C), Bausch&Lomb (C), Bayer Schering Pharma (C), Heidelberg (C), Novartis (C), Zeiss (C)
  • Footnotes
    Support  none
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 4960. doi:
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      Livia Tomasso, Lucia Benatti, Federico Corvi, Fatemeh Darvizeh, Giovanni Baldin, Adriano Carnevali, Lea Querques, Ilaria Zucchiatti, Francesco Bandello, Giuseppe Querques; DYNAMIC FUNCTIONALITY OF RETINAL VESSELS IN EYES WITH CENTRAL SEROUS RETINOPATHY. Invest. Ophthalmol. Vis. Sci. 2016;57(12):4960.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To analyze static characteristics and dynamic functionality of retinal vessels in eyes with central serous retinopathy (CSC) by means of Dynamic Vessel Analyzer (DVA).

Methods : Patients presenting with CSC and normal subjects (controls) matched for age and sex between May 2015 and November 2015 were enrolled in the study. Participants underwent complete ophthalmologic examination, including optical coherence tomography, dynamic and static retinal vessels analysis.

Results : A total of 28 eyes of 28 subjects (14 eyes for each group) were included in the analysis. Dynamic analysis during stimulation by flickering light showed mean venous dilation of 3.1±1.6% in CSC patients and 5.3±2.6% in healthy eyes (p=0.005); mean arterial dilation was 3.2±2.5% and 4.1±1.53%, respectively (p=0.28). Static retinal analysis in CSC patients showed a mean Central Retinal Artery Equivalent (CRAE) of 191±19, a mean Central Retinal Vein Equivalent (CRVE) of 216±18 and a mean arteriovenous ratio (AVR) of 0.88± 0.08. In control subjects mean CRAE was 189±16 and mean CRVE 212±19 (p= 0.887 and p=0.65 respectively vs respective measurements in CSC) and mean AVR was 0.89±0.04 (p=0.695). Choroidal thickness was 451±79 µm in CSC eyes, significantly increased compared to control subjects (301±72, p<0.001).

Conclusions : Dynamic analysis revealed a reduced retinal venous dilation in response to flicker light stimulation in CSC eyes. The impaired retinal vascular function together with the increased choroidal thickness may help understanding CSC and give insights in its pathogenesis.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

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