September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Optical coherence tomography angiography in treatment-naïve quiescent choroidal neovascularization
Author Affiliations & Notes
  • Adriano Carnevali
    U.O. Oculistica, Università Magna Graecia Catanzaro, Catanzaro, Calabria , Italy
    IRCCS Ospedale San Raffaele, Milano, Italy
  • Andrea Mazzaferro
    IRCCS Ospedale San Raffaele, Milano, Italy
  • Federico Corvi
    IRCCS Ospedale San Raffaele, Milano, Italy
  • maria vittoria cicinelli
    IRCCS Ospedale San Raffaele, Milano, Italy
  • Eleonora Corbelli
    IRCCS Ospedale San Raffaele, Milano, Italy
  • Vittorio Capuano
    Université Paris-Est - Créteil, Paris, France
  • Lea Querques
    IRCCS Ospedale San Raffaele, Milano, Italy
  • Vincenzo Scorcia
    U.O. Oculistica, Università Magna Graecia Catanzaro, Catanzaro, Calabria , Italy
  • Francesco Bandello
    IRCCS Ospedale San Raffaele, Milano, Italy
  • Giuseppe Querques
    IRCCS Ospedale San Raffaele, Milano, Italy
  • Footnotes
    Commercial Relationships   Adriano Carnevali, None; Andrea Mazzaferro, None; Federico Corvi, None; maria vittoria cicinelli, None; Eleonora Corbelli, None; Vittorio Capuano, None; Lea Querques, None; Vincenzo Scorcia, None; Francesco Bandello, Alcon (C), Alimera Science (C), Allergan (C), Bausch&Lomb (C), Bayer (C), Farmila Thea (C), Genentech (C), Hofmann La Roche (C), Novagali Pharma (C), Novartis (C), Sanofi Aventis (C), Thrombogenics (C); Giuseppe Querques, Alimera (C), Allergan (C), Bausch and Lomb (C), Bayer schering pharma (C), Heidelberg (C), Novartis (C), Zeiss (C)
  • Footnotes
    Support  none
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 4962. doi:
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      Adriano Carnevali, Andrea Mazzaferro, Federico Corvi, maria vittoria cicinelli, Eleonora Corbelli, Vittorio Capuano, Lea Querques, Vincenzo Scorcia, Francesco Bandello, Giuseppe Querques; Optical coherence tomography angiography in treatment-naïve quiescent choroidal neovascularization. Invest. Ophthalmol. Vis. Sci. 2016;57(12):4962.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To describe the optical coherence tomography angiography (OCT-A) features of treatment-naïve “quiescent” choroidal neovascularization (CNV) secondary to age-related macular degeneration (AMD).

Methods : Nine consecutive patients with treatment-naïve quiescent CNV secondary to AMD consecutively presenting between September 2015 and November 2015 at the Retina Service of the Department of Ophthalmology of the University Vita-Salute San Raffaele in Milan were enrolled in this study. Patients underwent multimodal imaging assessment including FA, ICGA, SD-OCT and OCT-A. The size and appearance of quiescent CNV on OCT-A were evaluated. OCT-A was performed through a prototype OCT-A (AngioPlex, CIRRUS HD-OCT models 5000, Carl Zeiss Meditec, Inc., Dublin, USA). The automatic segmentation provided by the machine software was manually adjusted by two expert retinal specialists (G.Q. and F.C.), to ensure correct visualization of the capillary plexuses, outer retinal layers, choriocapillaris layer, and identification of the CNV plane. CNV size was classified as “small” if greatest linear dimension (GLD) was less than 1 mm, “medium” if GLD was between 1 and 2 mm, and “large” if GLD was more than 2 mm. CNV on OCT-A were classified in well circumscribed (seafan-shaped vessels) or poorly circumscribed (long filamentous vessels) on the bases of its appearance and its borders.

Results : Ten eyes of 9 consecutive patients (4 Female / 5 Male; mean age 75.6±9 years) with quiescent CNV secondary to AMD were included in the analysis. All eyes evaluated in this study demonstrated agreement between OCTA and FA, ICGA, and SD-OCT images with respect to treatment-naïve quiescent CNV identification. CNV size on OCT-A was small in 7 eyes (70%), medium in 2 eyes (20%) and large in 1 eye (10%). CNV appeared as well circumscribed in 7 eyes (70%) and poorly circumscribed in 3 eyes (30%).

Conclusions : Using OCTA allows the clinician to visualize CNV noninvasively and may provide a method for identifying even treatment-naive quiscent CNV and possibly guiding treatment.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

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