September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Relationship between foveal ellipsoid zone integrity and central visual function in age related macular degeneration
Author Affiliations & Notes
  • Noelia Pitrelli Vazquez
    Eye and Vision Science, Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool, United Kingdom
  • Simon P Harding
    Eye and Vision Science, Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool, United Kingdom
    Royal Liverpool University Hospital, Liverpool, United Kingdom
  • Heinrich Heimann
    Royal Liverpool University Hospital, Liverpool, United Kingdom
  • Paul C Knox
    Eye and Vision Science, Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool, United Kingdom
  • Footnotes
    Commercial Relationships   Noelia Pitrelli Vazquez, None; Simon Harding, None; Heinrich Heimann, None; Paul Knox, Vital Art & Science Inc (F)
  • Footnotes
    Support  The Dunhill Medical Trust Grant n. R283/0213
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 4969. doi:
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      Noelia Pitrelli Vazquez, Simon P Harding, Heinrich Heimann, Paul C Knox; Relationship between foveal ellipsoid zone integrity and central visual function in age related macular degeneration. Invest. Ophthalmol. Vis. Sci. 2016;57(12):4969.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Lack of ellipsoid zone (EZ) hyper-reflectivity in high resolution optical coherence tomography (OCT) has been associated with poor retinal sensitivity at corresponding retinal loci measured by microperimetry. We investigated the relationship between EZ hyper-reflectivity over the foveal area and two measurements of central visual function: shape discrimination hyperacuity (SDH) and best corrected visual acuity (BCVA) in eyes at risk of developing late age-related macular degeneration (AMD).

Methods : Patients attending hospital to receive treatment for neovascular AMD (nAMD) to their first eye performed BCVA, SDH and Heidelberg Spectralis OCT with their fellow eye (study eye, SE), which was required to have no evidence of nAMD or central geographic atrophy. EZ hyper-reflectivity was assessed in all B-scans lines falling within the foveal area (1200µm in diameter) and measured using the software provided calliper. The sums of the lengths of each line where hyper-reflectivity was intact and abnormal /absent were calculated and transformed into a percentage of the total. A grade of “0” was given when the EZ was intact, “1” when <20% of the EZ was abnormal/absent and 2 when >20% of abnormal/absent EZ was present.

Results : Of 78 SEs [mean participant age 77±8 years (range 57 to 91); 49 females], 33 (42%) were graded as “0”. For these, mean (95%CI) SDH and BCVA were: -0.62 (-0.68 to -0.57) and 0.06 (0.01 to 0.1) logMAR. For 17 eyes (22%) graded as “1” SDH and BCVA were -0.59 (-0.66 to -0.52) and 0.04 (0.02 to 0.1) logMAR respectively. For 28 (36%) graded as “2”, SDH and BCVA were -0.50 (-0.56 to -0.45) and 0.06 (0.01 to 0.1) logMAR respectively. After adjusting for the effect of age, the EZ grade had a significant negative effect on SDH score [F(2,74)=4.94, p=0.01, Partial η2=0.12] but not on BCVA [F(2,74)=0.13, p=0.89, Partial η2=0.003]. Planned contrasts revealed that SDH was significantly decreased only when EZ was graded as 2 compared to 0 [t(74)=-3.1, p=0.03, r=0.12].

Conclusions : There was a small but still statistically significant decrease in SDH observed in eyes with greater EZ abnormality, which was not seen for BCVA. As these measurements of central vision are comparable in terms of ease of use and task simplicity, our results indicate that SDH might be a better marker of photoreceptor dysfunction in early/intermediate AMD than BCVA.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

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