September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Ganglion Cell Complex Thickness in Mitochondrial Optic Neuropathies
Author Affiliations & Notes
  • Starleen E Frousiakis
    University of Southern California, Pasadena, California, United States
  • Jack Jiakun Tian
    David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California, United States
  • Alexandria Lee
    Ophthalmology, UCLA, Los Angeles, California, United States
  • Jeffrey Tran
    University of Southern California, Pasadena, California, United States
  • Anna Ter-Zakarian
    Doheny Eye Institute, Los Angeles, California, United States
  • Kaitlin Kogachi
    University of Southern California, Pasadena, California, United States
  • Jesse Gale
    Doheny Eye Institute, Los Angeles, California, United States
  • Fred N. Ross-Cisneros
    Doheny Eye Institute, Los Angeles, California, United States
  • Luis Dimen
    Huntington Memorial Hospital, Pasadena, California, United States
  • Rustum Karanjia
    Doheny Eye Institute, Los Angeles, California, United States
  • Alfredo A Sadun
    Doheny Eye Institute, Los Angeles, California, United States
  • Footnotes
    Commercial Relationships   Starleen Frousiakis, None; Jack Tian, Edison Pharmaceuticals (F); Alexandria Lee, None; Jeffrey Tran, None; Anna Ter-Zakarian, None; Kaitlin Kogachi, None; Jesse Gale, None; Fred Ross-Cisneros, None; Luis Dimen, None; Rustum Karanjia, Stealth (E); Alfredo Sadun, Edison (F), Stealth (F), Stealth (E)
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 5074. doi:
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      Starleen E Frousiakis, Jack Jiakun Tian, Alexandria Lee, Jeffrey Tran, Anna Ter-Zakarian, Kaitlin Kogachi, Jesse Gale, Fred N. Ross-Cisneros, Luis Dimen, Rustum Karanjia, Alfredo A Sadun; Ganglion Cell Complex Thickness in Mitochondrial Optic Neuropathies. Invest. Ophthalmol. Vis. Sci. 2016;57(12):5074.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Our lab and others have shown that the ganglion cell complex (GCC) - the sum of the retinal nerve fiber, ganglion cell and inner plexiform layers - is reduced in patients affected with Leber’s Hereditary Optic Neuropathy [Balducci, 2015, and Akiyama, 2013]. The purpose of this study was to determine if this finding is consistent in all patients affected by mitochondrial optic neuropathies (MON).

Methods : A retrospective chart review was conducted to identify all patients with mitochondrial optic neuropathies who presented to our clinic over a 1-year period and had both a central scotoma demonstrated on visual field and who had undergone a macular cube scan for GCC analysis (HD-OCT (Zeiss Meditech)). Forty-five subjects affected with LHON (n1=41) or dominant optic atrophy (n2=4) were identified.

Results : All patients affected with a MON had a reduction in the GCC layer in all quadrants of greater than 2 standard deviations when compared to age-matched controls. The average GCC thickness was 59.5±19.9µm. There was no significant difference between quadrants. Both LHON and DOA patients showed a similar decrease in GCC thickness.

Conclusions : The pattern of GCC loss and RNFL thinning appears to be a consistent finding in MON. This suggests that GCC may be a useful metric for patients with MON, particularly if used in conjunction with retinal nerve fiber layer thickness.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

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