September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Relationship between foveal cone structure and visual acuity measured with adaptive optics scanning laser ophthalmoscopy (AOSLO) in retinal degenerations and normal subjects.
Author Affiliations & Notes
  • Panagiota Loumou
    Ophthalmology, University of California San Francisco, San Francisco, California, United States
  • Shane Griffin
    Ophthalmology, University of California San Francisco, San Francisco, California, United States
  • Kavitha Ratnam
    School of Optometry and Vision Science Graduate Group, University of California Berkeley, Berkeley, California, United States
  • Travis Porco
    Proctor Foundation, University of California San Francisco, San Francisco, California, United States
  • Jia Qin
    Ophthalmology, University of California San Francisco, San Francisco, California, United States
  • Austin Roorda
    School of Optometry and Vision Science Graduate Group, University of California Berkeley, Berkeley, California, United States
  • Jacque L Duncan
    Ophthalmology, University of California San Francisco, San Francisco, California, United States
  • Footnotes
    Commercial Relationships   Panagiota Loumou, None; Shane Griffin, None; Kavitha Ratnam, None; Travis Porco, None; Jia Qin, None; Austin Roorda, University of Rochester, University of Houston (P); Jacque Duncan, None
  • Footnotes
    Support  NIH Grant EY023591, NIH Grant EY002162, FDA R01-41001, Research to Prevent Blindness, The Bernard A. Newcomb Macular Degeneration Fund, That Man May See, Inc., Hope for Vision, Foundation Fighting Blindness, Beckman Initiative for Macular Research Grant 1201, Claire Giannini Foundation
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 5108. doi:
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    • Get Citation

      Panagiota Loumou, Shane Griffin, Kavitha Ratnam, Travis Porco, Jia Qin, Austin Roorda, Jacque L Duncan; Relationship between foveal cone structure and visual acuity measured with adaptive optics scanning laser ophthalmoscopy (AOSLO) in retinal degenerations and normal subjects.. Invest. Ophthalmol. Vis. Sci. 2016;57(12):5108.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To assess foveal cone structure and function using AOSLO in patients with inherited retinal degenerations (IRD) and normal subjects. AO correction can minimize aberrations that influence visual acuity and resolution of retinal images, permitting evaluation of foveal cone structure with single cell resolution.

Methods : High-resolution images of the cone mosaic were obtained with AOSLO from 7 eyes of 4 normal subjects and 23 eyes of 14 patients with IRD in whom AOSLO images showed resolved cones within 0.5 degrees of the preferred retinal location (PRL). AOSLO visual acuity threshold measurements modulated the scanning laser to directly project letters onto the retina and subjects reported the orientation of the tumbling E. The average threshold was converted into logMAR acuity. Cone spacing was measured close to or at the PRL center (mean eccentricity, 0.16 degree; maximum eccentricity, 0.24 degree) by 2 independent graders within a standardized 0.1 degree2 box. Cone spacing measures were correlated with best-corrected (ETDRS) visual acuity, foveal threshold, outer segment (OS) thickness and AOSLO visual acuity, correcting for eccentricity. Relationships were assessed with Spearman rho using clustered bootstrap for 95% confidence interval (CI) values.

Results : Cone spacing was significantly correlated with ETDRS acuity (rho = -0.66, 95% CI -0.85 to -0.26, P < 0.01); the correlation was significant for IRD patients (P = 0.026, clustered bootstrap), but not normal subjects (P = 0.33, mixed model). Cone spacing showed a significant, negative correlation with foveal threshold (rho = -0.70, 95% CI: -0.82 to -0.34) and OS thickness (rho=-0.73, 95% CI: -0.89 to -0.39). Cone spacing was significantly correlated with visual acuity measured using AOSLO in all subjects combined (P = 0.028) and in IRD patients (P = 0.045), but not in normal subjects alone (P = 0.48, mixed model). AOSLO acuity was strongly correlated with ETDRS visual acuity (rho = -0.73, 95% CI = -0.88 to -0.36, P < 0.01).

Conclusions : Measures of visual acuity using ETDRS and AOSLO correction showed a linear correlation with cone spacing in patients with IRD, but not normal subjects, perhaps due to variability in foveal cone density in normal eyes. AOSLO cone measures and visual acuity may provide more sensitive measures of foveal function than standard measures.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

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