September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Anterior Segment Parameters in Subjects with Asymmetric Primary Angle Closure Glaucoma
Author Affiliations & Notes
  • Monisha Esther Nongpiur
    Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore
    Duke-NUS Medical School, Singapore, Singapore
  • Kenric R Fan
    Yong Loo Lin School of Medicine, National University of Singapore, Singapore , Singapore
  • Jestin W Chiew
    Yong Loo Lin School of Medicine, National University of Singapore, Singapore , Singapore
  • Yap Sae Cheong
    Yong Loo Lin School of Medicine, National University of Singapore, Singapore , Singapore
  • Shamira Perera
    Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore
    Duke-NUS Medical School, Singapore, Singapore
  • Tin Aung
    Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore
    Yong Loo Lin School of Medicine, National University of Singapore, Singapore , Singapore
  • Footnotes
    Commercial Relationships   Monisha Nongpiur, None; Kenric Fan, None; Jestin Chiew, None; Yap Cheong, None; Shamira Perera, None; Tin Aung, None
  • Footnotes
    Support  National Medical Research Council, Singapore (STAR: NMRC/STAR/0023/2014)
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 5123. doi:
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      Monisha Esther Nongpiur, Kenric R Fan, Jestin W Chiew, Yap Sae Cheong, Shamira Perera, Tin Aung; Anterior Segment Parameters in Subjects with Asymmetric Primary Angle Closure Glaucoma. Invest. Ophthalmol. Vis. Sci. 2016;57(12):5123.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To investigate the association between anterior segment parameters and asymmetric primary angle closure glaucoma (PACG).

Methods : Two hundred and fifty eight subjects with PACG in at least one eye were recruited from glaucoma clinics. Each subject underwent anterior-segment optical coherence tomography (AS-OCT, Visante, Carl Zeiss Meditec, Dublin, CA) imaging, gonioscopy and visual field (VF) assessment. Visual field asymmetry was defined as a five point difference between the eyes using the Advanced Glaucoma Intervention Study (AGIS) scoring system; and unilateral VF defect was defined as an AGIS score of 0 in the better eye and an interocular score asymmetry of ≥5.

Results : Based on the study definitions, 53 subjects (20.5%) had VF asymmetry and 33 (12.8%) had unilateral VF defect. The mean age of the 53 subjects was 62.1±7.3 years and there were 26 (49.1%) females. Compared to the better eyes, the worse eyes had significantly higher presenting intraocular pressure (IOP, 32.7±15.7 vs 18.7±8.1; p<0.001), greater vertical-cup-disc ratio (p<0.001) and use of more glaucoma medications (p<0.001). The worse eyes of those with VF asymmetry were also characterized by significantly smaller anterior chamber width (ACW, p=0.02) and smaller posterior corneal arc length (PCAL, p=0.016). The analysis in subjects with unilateral VF defect was largely similar, with the affected eye characterized by significantly narrower gonioscopic angle width (p=0.004), smaller ACW (p=0.01), smaller PCAL (p=0.006), and smaller anterior vault (p=0.015).

Conclusions : In our clinic-based study of PACG, we observed that 20% of the subjects had VF asymmetry and about 12% had unilateral VF defect. Asymmetric PACG was associated with asymmetry in anterior segment parameters.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

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