September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Extracellular matrix in retinal vascular development and pathological angiogenesis
Author Affiliations & Notes
  • Paul N Bishop
    Centre for Ophthalmology & Vision Sciences, University of Manchester, Manchester, United Kingdom
    Manchester Royal Eye Hospital, Central Manchester University Hospitals NHS Foundation Trust, Manchester, United Kingdom
  • Footnotes
    Commercial Relationships   Paul Bishop, Opticin Ltd. (I)
  • Footnotes
    Support  MRC DPFS Ref: MR/M025365/1
Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:
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      Paul N Bishop; Extracellular matrix in retinal vascular development and pathological angiogenesis. Invest. Ophthalmol. Vis. Sci. 201657(12):.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Presentation Description : Extracellular matrix, in the form of basement membrane, is a central component of vasculature. Matrix also provides an essential substrate for blood vessel growth and different matrix components provide templates for retinal vascular development and pathological angiogenesis. Whilst some matrix components stimulate angiogenesis/vasculogenesis, others inhibit the process. These stimulatory and inhibitory matrix components induce outside-to-inside signalling in endothelial cells, particularly through integrins; so matrix makes an important contribution to the angiogenic balance in the retina and adjacent structures.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

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