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Kotomi Suzuki, Takeshi Mizutani, Miho Nozaki, Aki Kato, Munenori Yoshida, Yuichiro Ogura; Persistent choroidal neovascularization in high myopia detected by optical coherence tomography angiography. Invest. Ophthalmol. Vis. Sci. 2016;57(12):5339.
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© ARVO (1962-2015); The Authors (2016-present)
Optical coherence tomography angiography (OCTA) is a newly developed technology which can visualize chorioretinal microcirculation without dye injection. The purpose of this study was to evaluate myopic choroidal neovascularization (CNV) by OCTA.
The study design was a retrospective chart review of 11 patients (14 eyes) with mCNV who could maintain fixation during the scan process. The eyes were scanned using OCTA (3 × 3 mm). OCTA was performed using XR Avanti OCT (Optovue, Fremont, CA). All patients were women, and average age was 56.4±12.2 years old. Nine eyes were also evaluated by fluorescein angiography (FA) and Indocyanine green angiography (ICGA) using HRA2 (Heidelberg, Engineering, Dossenheim, Germany). Myopic CNV was defined as the CNV, which occurred in the eyes with refractive error of greater than or equal to -6 diopters.
The AngioVue system can divide the retina-choroid layer into 4 layers: the superficial capillary plexuses, deep capillary plexuses, outer retina and choroidal vessels. Myopic CNV were found in outer retina in all eyes. In 2 eyes of 14 eyes (14.2 %), myopic CNV was also found in the superficial capillary plexuses due to retinal thinning. In the eyes treated with anti-VEGF therapy, we could quantify the area of CNV, and follow the regression of CNV. In twelve eyes without deterioration of visual acuity nor exudative changes in the retina, CNV were found by OCTA, and myopic CNV still remained without activity of neovascularization.
Since myopic CNV is type 2 CNV, OCTA could clearly detect myopic CNV in outer retina. Our results showed that OCTA was useful in making diagnosis and follow-up in the eyes with myopic CNV. However, our findings indicated that OCTA could detect peristent CNV in high myopia, making decision of treatment for myopic CNV should be considered with visual symptom, OCT B-scan and OCTA.
This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.
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