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Reina Okada, Manabu Yamamoto, Kumiko Hirayama, Ayako Yasui, Takeya Kohno, Dirk Theisen-Kunde, Yoko Miura, Ralf Brinkmann, Kunihiko Shiraki; Fundus Autofluorescence at Test Irradiation Spots after Selective Retina Therapy for Central Serous Chorioretinopathy.. Invest. Ophthalmol. Vis. Sci. 2016;57(12):5345.
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© ARVO (1962-2015); The Authors (2016-present)
To evaluate changes in fundus autofluorescence (FAF) images at test irradiation in patients with central serous chorioretinopathy (CSC) after Selective Retina Therapy (SRT).
Twenty three eyes of 23 CSC patients consisting of 17 males and 6 females were treated. Mean age was 51 years old (range 29 – 68 years old). All subjects had leakage measured by fluorescein angiography (FA) and persistent serous retinal detachment at the subfovea longer than 3 months. SRT laser (frequency-doubled, pulse-stretched Nd:YLF laser; 527 nm, 1.7 µs pulse duration, 100-Hz repetition rate, Medical Laser Center Lübeck, Germany) was used for treatment. Following test spots to determine the irradiation energy around the upper or lower vessel arcade, the treatment was performed at the leakage point on FA. FAF images of test irradiation were detected by two devices, the fundus camera (FC) (TRC-50AX, Topcon, Tokyo) and scanning laser ophthalmoscope (SLO) (Heidelberg Spectralis, Heidelberg, Germany). FAF findings were divided into hyper- or hypoautofluorescence, which were classified as plus detected with either or both device at 1, 3, 6 and 12 months postoperatively. The correlation between FAF findings and optoacoustic (OA) value was examined.
One hundred and 71 test spots were included. Mean irradiation energy was 97 mJ (range 49 -161 mJ) and mean logarithm OA value was 2.35 (range 1.28 - 4.18). The rate of hyperautofluorescence findings decreased as time proceeds compared with 1 month (64%, 40%, 30% and 27% at 1, 3, 6, 12 months postoperatively, respectively). The rate of hypoautofluorescence findings were unchangeable in the full observation period (73%, 73%, 74% and 73% at 1, 3, 6, 12 months postoperatively, respectively). The OA values of the test spots presented hyper- or hypoautofluorescence findings were significantly high compared with no FAF findings.
Hyperautofluorescence after SRT decreased as time proceeds, while hypoautofluorescence remained for 1 year. The high OA value might affect damage around retinal pigment epithelium for long periods.
This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.
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