September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Screening subjects for an extended and long-term observation of pathologic myopia at hypothesized risk for developing a myopic choroidal neovascularization
Author Affiliations & Notes
  • Petrus Chang
    GRADE Reading Center, Department of Ophthalmology, University of Bonn, Bonn, Germany
  • Focke Ziemssen
    Department of Ophthalmology, Eberhard-Karl University Tuebingen, Tuebingen, Germany
  • Nicole Eter
    Department of Ophthalmology, University of Muenster, Muenster, Germany
  • Christian Karl Brinkmann
    GRADE Reading Center, Department of Ophthalmology, University of Bonn, Bonn, Germany
  • Gisela Haeusser-Fruh
    Novartis Pharma Nuremberg, Nuremberg, Germany
  • Marc Schargus
    OSG Augenklinik Schweinfurt-Gerolzhofen, Schweinfurt-Gerolzhofen, Germany
  • Frank G Holz
    GRADE Reading Center, Department of Ophthalmology, University of Bonn, Bonn, Germany
  • Steffen Schmitz-Valckenberg
    GRADE Reading Center, Department of Ophthalmology, University of Bonn, Bonn, Germany
  • Footnotes
    Commercial Relationships   Petrus Chang, None; Focke Ziemssen, Novartis Germany (C); Nicole Eter, Novartis (C), Novartis (F), Novartis (R); Christian Brinkmann, None; Gisela Haeusser-Fruh, Novartis Germany (E); Marc Schargus, None; Frank Holz, Novartis (F); Steffen Schmitz-Valckenberg, Novartis (F), Novartis (C)
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 5348. doi:
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      Petrus Chang, Focke Ziemssen, Nicole Eter, Christian Karl Brinkmann, Gisela Haeusser-Fruh, Marc Schargus, Frank G Holz, Steffen Schmitz-Valckenberg; Screening subjects for an extended and long-term observation of pathologic myopia at hypothesized risk for developing a myopic choroidal neovascularization. Invest. Ophthalmol. Vis. Sci. 2016;57(12):5348.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : This prospective study conducted in German in high myopic Caucasians with pre-defined disease patterns aims to record the natural history over three years in order to identify potential risk factors for the development of myopic choroidal neovascularization (mCNV).

Methods : This is a non-interventional study with yearly visits, targeting enrollment of 250 subjects in 30 German centers. At each visit, the assessments include the completion of a standardized history, ophthalmic exam, and acquisition of multimodal retinal imaging. In addition to an axial length ≥ 26 mm, at least one of the following five disease patterns has to be present in the study eye for inclusion: (1) subfoveal choroidal thinning < 50 µm, (2) choroidal curvature length >6300µm, (3) lacquer cracks, (4) patchy atrophy > 5 mm2 or (5) preexisting mCNV in the fellow eye. Eligibility is independently confirmed by a central reading center (CRC).

Results : For an interim analysis of baseline data, a total of 191 subjects (mean age: 53.0 years, range 18.2-86.2; mean axial length 30.1 mm, range 26.0 – 35.7) were screened for eligibility by the CRC. The presence of at least one of the five pre-defined disease patterns was confirmed in 100 (52%) subjects (mean age: 56.6 years, range 21.9 – 86.2). The most common disease pattern was subfoveal choroidal thinning (n = 34), followed by lacquer cracks (n = 31), preexisting mCNV in the fellow eye (n = 18), followed by patchy atrophy (n = 14). Finally, a choroidal curvature length >6300 µm was found in three subjects with an axial length of 34.9 mm. In 51 subjects, more than one of the five disease patterns was present in the study eye. The mean axial length of the enrolled subjects was 30.1 mm (range, 26.0 – 35.7).

Conclusions : Within the prospective study cohort, there seems to be a high variability between the extent of eye globe elongation and the presence of disease patterns in myopic subjects. Identification of high risk features for the development of mCNV appears to be important for patient management and visual long-term outcome.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

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