September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Circulating biomarkers of inflammation, oxidative stress and vascular risk for diabetic retinopathy. Effects of a nutraceutical supplementation in two year follow-up
Author Affiliations & Notes
  • Maria D Pinazo-Duran
    Cell and Molecular Biology of the Eyes and Vision, Ophthalmic Research Unit Santiago Grisolia, Valencia, Spain
  • VICENTE C ZANON-MORENO
    Cell and Molecular Biology of the Eyes and Vision, Ophthalmic Research Unit Santiago Grisolia, Valencia, Spain
  • Silvia M Sanz-Gonzalez
    Cell and Molecular Biology of the Eyes and Vision, Ophthalmic Research Unit Santiago Grisolia, Valencia, Spain
  • Jose J Garcia-Medina
    Cell and Molecular Biology of the Eyes and Vision, Ophthalmic Research Unit Santiago Grisolia, Valencia, Spain
  • CARMEN GALBIS-ESTRADA
    Cell and Molecular Biology of the Eyes and Vision, Ophthalmic Research Unit Santiago Grisolia, Valencia, Spain
  • Elena Bendala-Tufanisco
    Medicine, Universidad Cardenal Herrera, Valencia, Spain
  • Rosa Dolz-Marco
    Ophthalmology, Hospital Universitario y Politecnico La Fe, Valencia, Spain
  • M Isabel Lopez
    Ophthalmology, Instituto de oftalmobiologia aplicada IOBA, Valladolid, Spain
  • Roberto Gallego-Pinazo
    Ophthalmology, Hospital Universitario y Politecnico La Fe, Valencia, Spain
  • Footnotes
    Commercial Relationships   Maria Pinazo-Duran, None; VICENTE ZANON-MORENO, None; Silvia Sanz-Gonzalez, None; Jose Garcia-Medina, None; CARMEN GALBIS-ESTRADA, None; Elena Bendala-Tufanisco, None; Rosa Dolz-Marco, None; M Isabel Lopez, None; Roberto Gallego-Pinazo, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 5429. doi:
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      Maria D Pinazo-Duran, VICENTE C ZANON-MORENO, Silvia M Sanz-Gonzalez, Jose J Garcia-Medina, CARMEN GALBIS-ESTRADA, Elena Bendala-Tufanisco, Rosa Dolz-Marco, M Isabel Lopez, Roberto Gallego-Pinazo; Circulating biomarkers of inflammation, oxidative stress and vascular risk for diabetic retinopathy. Effects of a nutraceutical supplementation in two year follow-up. Invest. Ophthalmol. Vis. Sci. 2016;57(12):5429.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To analyze levels of circulating biomarkers involved in inflammation, oxidative stress and vascular risk that can presumptively predict progression of diabetic retinopathy (DR) in type 2 diabetics (T2DM) from the Valencia Study on Diabetic Retinopathy (VSDR) cohort.

Methods : All experiments were done according to the ARVO and EC guidelines for research. 177 participants were distributed into: 1) T2DG; n=102 and 2) controls (CG; n=75) after initial baseline assessment. Interview, ophthalmic examination [including retinal color photographs (RCP), optic coherence tomography (OCT)] and collecting blood (that was frozen until processing to biochemical/molecular approaches) was done to all participants. Participants from each group were randomly assigned (or not) to a daily intake of one pill containing antioxidants/omega 3 fatty acids (A/w3). Data were taken at baseline and every 6 months during the 2 year follow-up. Statistical processing was done by the SPSS 15.0.

Results : Association of levels of homocysteine (Hcys), vitamin B12/folic acid (VitB12/fa), interleukin 6 (IL6), malondialdehyde (MDA/TBATS), total antioxidant capacity (TAC) and glutathione (GSH) were assessed with DR endpoints that were determined from clinical criteria based on RCP/OCT data. Hcys (p=0.032), vitB12/fa (p=0.050), IL-6 (p=0.050), MDA/TBARS ( p=0.030), TAC (p=0.001) and GSH (p=0.031) plasmatic levels significantly changed in the T2DG with/without DR respect to the CG. After 2 year follow-up significantly reduced Hcys (p=0.047), IL6 (p=0.001) and MDA/TBARS (p=0.000), and increased vit B12/fa (p=0.037), TAC (p=0.050) and GSH (p=0.000) plasmatic concentrations were detected in the A/w3 supplemented vs the no supplemented T2DM, as compared to baseline

Conclusions : After adjusting for age, gender, personal characteristics and risk factors, T2DM was strongly associated with oxidative stress, compromised vascular function and altered immune response circulating biomarkers, that can be used as dynamic monitoring factors for detecting DR progression. The oral supplementation with A/w3 may exert additional benefits in T2DM.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

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