September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Optical Coherence Tomography Angiography Assessment of the Deep Retinal Capillary Plexus in Patients With Diabetic Retinopathy
Author Affiliations & Notes
  • Roberto Gallego-Pinazo
    Unit of Macula. Ophthalmology Department, Univ & Polytechnic Hosp La Fe, Valencia, Spain
    Retics Oftared (RD12/0034), Prevention, Early Detection And Treatment Of The Prevalent Degenerative And Chronic Ocular Pathology, Institute of Health Carlos III, Madrid, Spain
  • LAURA MONJE-FERNANDEZ
    Unit of Macula. Ophthalmology Department, Univ & Polytechnic Hosp La Fe, Valencia, Spain
    Ophthalmology department, University Hospital Complex of León, Leon, Spain
  • María Andreu-Fenoll
    Unit of Macula. Ophthalmology Department, Univ & Polytechnic Hosp La Fe, Valencia, Spain
    Institute for Health Research, University and Polytechnic Hospital La Fe, Valencia, Spain
  • Nestor Garcia-Marin
    Unit of Macula. Ophthalmology Department, Univ & Polytechnic Hosp La Fe, Valencia, Spain
    Institute for Health Research, University and Polytechnic Hospital La Fe, Valencia, Spain
  • Rosa Dolz-Marco
    Institute for Health Research, University and Polytechnic Hospital La Fe, Valencia, Spain
    Unit of Macula. Ophthalmology Department, Univ & Polytechnic Hosp La Fe, Valencia, Spain
  • Footnotes
    Commercial Relationships   Roberto Gallego-Pinazo, Alcon (F), Bayer (F), Heidelberg Engineering (F), Novartis (F), Novartis (C); LAURA MONJE-FERNANDEZ, None; María Andreu-Fenoll, None; Nestor Garcia-Marin, None; Rosa Dolz-Marco, Alcon (F), Heidelberg Engineering (F), Novartis (F)
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 5486. doi:
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      Roberto Gallego-Pinazo, LAURA MONJE-FERNANDEZ, María Andreu-Fenoll, Nestor Garcia-Marin, Rosa Dolz-Marco; Optical Coherence Tomography Angiography Assessment of the Deep Retinal Capillary Plexus in Patients With Diabetic Retinopathy. Invest. Ophthalmol. Vis. Sci. 2016;57(12):5486.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To describe the correlation between conventional high-definition optical coherence tomography (OCT) and optical coherence tomography angiography (OCT-A) in patients with diabetic retinopathy and deep retinal capillary ischemia.

Methods : Patients with diabetic retinopathy were analyzed by OCT and OCT-A (Heidelberg Engineering) macular scan and those showing any degree of deep retinal capillary plexus dropout were included in the present study. A qualitative correlation between areas of preserved and damaged deep capillary plexus as observed with OCT-A, and the morphometric appearance of them in the corresponding OCT scans was performed. Patients with cystoid retinal changes were excluded from the analysis in order to avoid possible bias induced by the disrupted retinal anatomy in such cases.

Results : A total number of 20 eyes of 10 diabetic patients (7 men and 3 women; age range: 25-72 years). A robust and constant qualitative association was evidenced between areas of deep retinal capillary ischemia and focal thinning of the INL. Deep capillary ischemic changes were evidenced to show a honeycomb distribution in the OCT-A images that was translated into a wreath-like contour of the INL in the corresponding sectional OCT scan.

Conclusions : The advent of OCT-A is one of the most exciting advances within the field of macular diseases. For the first time we are able to clearly differentiate and visualize both the superficial and deep retinal capillary plexi. Patients with retinal vascular diseases may benefit from this new imaging modality as changes at the level of the deep plexus have an increasing role in their prognosis. We have found a consistent correlation between areas of INL thining in the conventional OCT scans with the deep capillary dropout in the OCT-A images, suggesting that the OCT changes may constitute an indirect sign of those ischemic changes.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

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