September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016

Longitudinal analysis of the foveal avascular zone in diabetic retinopathy using optical coherence tomography angiography.
Author Affiliations & Notes
  • YIJUN CAI
    Moorfields Eye Hospital, London, United Kingdom
    Barts and the London School of Medicine and Dentistry, London, United Kingdom
  • Jibran Mohamed-Noriega
    Moorfields Eye Hospital, London, United Kingdom
  • Pearse Andrew Keane
    Moorfields Eye Hospital, London, United Kingdom
  • Catherine A Egan
    Moorfields Eye Hospital, London, United Kingdom
  • Adnan Tufail
    Moorfields Eye Hospital, London, United Kingdom
  • Dawn A Sim
    Moorfields Eye Hospital, London, United Kingdom
  • Footnotes
    Commercial Relationships   YIJUN CAI, None; Jibran Mohamed-Noriega, None; Pearse Keane, Allergan (R), Bayer (R), Heidelberg (R), Novartis (R), Topcon (R); Catherine Egan, None; Adnan Tufail, None; Dawn Sim, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 5498. doi:
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      YIJUN CAI, Jibran Mohamed-Noriega, Pearse Andrew Keane, Catherine A Egan, Adnan Tufail, Dawn A Sim;
      Longitudinal analysis of the foveal avascular zone in diabetic retinopathy using optical coherence tomography angiography.. Invest. Ophthalmol. Vis. Sci. 2016;57(12):5498.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To evaluate the variance of different methods for analyzing Optical Coherence Tomography Angiography (OCTA)- derived images of the foveal avascular zone (FAZ) in diabetic retinopathy.

Methods : Patients with evidence of diabetic retinopathy and OCTA imaging on two separate visits were included. A commercial OCTA system (AngioVue, Optovue, Inc. Fremont, CA, USA) was used to acquire 3x3mm images of the superficial and deep vessel layers, centered on the fovea. FAZ area (mm2), perimeter (mm), and circularity were analyzed using ImageJ. The F-test was used to compare the variances within each parameter in the superficial and deep vessel layers.

Results : 12 eyes of 6 patients were included. All eyes had been previously diagnosed with diabetic macular ischemia of varying severities; 4/12 (33.3%) questionable, 4/12 (33.3%) mild, 2/12 (16.7%) moderate, and 2/12 (16.7%) severe. The mean time between OCTA imaging was 104 days (range 56 to 210). In the superficial layer, the median difference (variance) in FAZ area was 0.045 (0.012), FAZ perimeter 0.243 (2.49), and FAZ circularity 0.001 (0.005). In the deep layers, median difference (variance) in FAZ area was 0.15 (0.016), FAZ perimeter 0.138 (2.55), and FAZ circularity 0.061 (0.005). There were no significant differences in the variance ratios for superficial and deep layer analysis of FAZ area 1.30 (p=0.67), perimeter 1.02 (p=0.91), or circularity 1.09 (p=0.88).

Conclusions : OCTA is non-invasive method for the rapid acquisition of images of the retinal vasculature. This promising new technology lends itself to longitudinal imaging in diabetic retinopathy for the purpose of monitoring of diabetic macular ischemia. We demonstrate the feasibility of using OCTA for this purpose and show that parameters such as area, perimeter and circularity can be used for quantification of the FAZ in both superficial and deep vessel layers.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

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