September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Age and oxidative stress in the retina
Author Affiliations & Notes
  • James T Handa
    Johns Hopkins Wilmer Eye Inst, Lutherville, Maryland, United States
  • Footnotes
    Commercial Relationships   James Handa, Bayer (F)
  • Footnotes
    Support  NIH EY14005, EY019904, RPB Senior Scientist Award
Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:
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      James T Handa; Age and oxidative stress in the retina. Invest. Ophthalmol. Vis. Sci. 201657(12):.

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      © 2017 Association for Research in Vision and Ophthalmology.

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Abstract

Presentation Description : The redox aging theory suggests that aging is the decline in the adaptive interface of the functional genome and the exposome that occurs due to cell and tissue differentiation, and cumulative injury resulting from an impaired response to oxidative stress. The high oxidative stress environment of the retina combined with the declining antioxidant response makes it vulnerable to oxidative damage. Nuclear factor-erythroid 2-related factor 2 (Nrf2) is a transcription factor that is induced by oxidative stress. The wingless (WNT) signaling pathway is a vast network of well-conserved lipid modified glycoproteins that influence changes in gene expression to govern cellular differentiation and survival, and its dysregulation has been implicated in aging, degenerative diseases, and carcinogenesis. WNT also has antioxidant capability as part of its role in survival. This talk will focus on the Nrf2 and WNT signaling systems and how their decline can be associated with retinal pigment epithelial cell dysfunction and death during aging and age-related macular degeneration.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

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