September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Mitochondrial dysfunction in the pathogenesis of age-related macular degene
Author Affiliations & Notes
  • Deborah A Ferrington
    University of Minnesota, Shoreview, Minnesota, United States
  • Footnotes
    Commercial Relationships   Deborah Ferrington, None
  • Footnotes
    Support  Elaine and Robert Larson Endowed Vision Research Chair; Beckman Initiative for Macular Research (#1004, #1303); Foundation Fighting Blindness (TA-NMT-0613-0620-UMN); An anonymous benefactor for Macular Degeneration Research; an unrestricted grant from Research to Prevent Blindness to the Department of Ophthalmology and Visual Neurosciences.
Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:
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      Deborah A Ferrington; Mitochondrial dysfunction in the pathogenesis of age-related macular degene. Invest. Ophthalmol. Vis. Sci. 201657(12):.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Presentation Description : Age-related Macular Degeneration (AMD) is a challenging disease to study due to the unique characteristics of the human eye, including the presence of a macula found only in primates, as well as the lengthy timeframe of >60 years to develop. Importantly, no animal model can faithfully recapitulate these features, further limiting our capacity to study disease mechanism. Our strategy has been to analyze human donor eyes graded for their stage of AMD, which has allowed us to capture key features of the disease. Results from our proteomic analysis and measures of mtDNA damage of the retina has provided solid evidence that the mitochondria is an early site of defect in the retinal pigment epithelium and thus, is a potential target for intervention.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

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