September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Morphological Evaluation of Meibomian Glands in Patients with Dry Eye Disease
Author Affiliations & Notes
  • Muhammed Yasin Adil
    Faculty of Medicine, University of Oslo, Oslo, Norway
    The Norwegian Dry Eye Clinic, Oslo, Norway
  • Jiaxin Xiao
    Faculty of Medicine, University of Oslo, Oslo, Norway
    The Norwegian Dry Eye Clinic, Oslo, Norway
  • Jonatan Olafsson
    Faculty of Medicine, University of Oslo, Oslo, Norway
  • Tor Paaske Utheim
    Unit of Regenerative Medicine, Department of Medical Biochemistry, Oslo University Hospital, Oslo, Norway
    Department of Ophthalmology, Vestre Viken Hospital Trust, Drammen, Norway
  • Sten Ræder
    The Norwegian Dry Eye Clinic, Oslo, Norway
  • Øygunn Aass Utheim
    Department of Ophthalmology, Oslo University Hospital, Oslo, Norway
  • Neil S Lagali
    Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden
  • Darlene A Dartt
    Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, United States
  • Xiangjun Chen
    The Norwegian Dry Eye Clinic, Oslo, Norway
    SynsLaser Surgery, Oslo, Norway
  • Footnotes
    Commercial Relationships   Muhammed Yasin Adil, None; Jiaxin Xiao, None; Jonatan Olafsson, None; Tor Utheim, None; Sten Ræder, None; Øygunn Utheim, None; Neil Lagali, None; Darlene Dartt, None; Xiangjun Chen, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 5676. doi:
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      Muhammed Yasin Adil, Jiaxin Xiao, Jonatan Olafsson, Tor Paaske Utheim, Sten Ræder, Øygunn Aass Utheim, Neil S Lagali, Darlene A Dartt, Xiangjun Chen; Morphological Evaluation of Meibomian Glands in Patients with Dry Eye Disease. Invest. Ophthalmol. Vis. Sci. 2016;57(12):5676.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To investigate the relationship between meibomian gland (MG) morphology and the ocular surface, and the MG morphology associated with aging and gender, in patients with symptoms of dry eye disease (DED).

Methods : Infrared meibography images of 100 right eyes of 100 patients were studied. Image analysis using ImageJ software was performed to evaluate MG loss (100-grade scale) in the upper (UL) and lower (LL) lids, as well as the MG length, thickness, and tortuosity in the UL. Their correlations with Ocular Surface Disease Index (OSDI), Dry Eye Severity Level (DESL), ocular staining (Oxford grading), tear osmolarity, tear break-up time (TBUT), Schirmer I test, and meibum quality and MG expressibility were investigated.

Results : Subjects were 41 females and 59 males; age 47.5±1.5 years, range 11 to 82. The MG loss was weakly correlated between the UL and LL (Pearson r=0.292, p=0.003), and MG loss was higher in the LL (median=58.8; UL 32.8; p<0.001). Male eyes demonstrated higher MG loss in the LL (p=0.005). Age correlated significantly with MG loss (r=0.267, p=0.007) and tortuosity (r=-0.362, p<0.001) in the UL only. In the UL, the MG loss correlated with MG expressibility (r=0.413, p<0.001); The MG length correlated significantly with the DESL (r=-0.212, p=0.042), ocular staining (r=-0.269, p=0.007), and MG expressibility (r=-0.448, p<0.001); the MG thickness correlated with OSDI (r=0.296, p=0.006); and MG tortuosity correlated with Schirmer I (r=0.260, p=0.009) and MG expressibility (r=-0.383, p<0.001). In the LL, the MG loss correlated with DESL (r=0.204, p=0.042), ocular staining (r=0.294, p=0.003), and MG expressibility (r= 0.279, p=0.007).

Conclusions : Meibomian gland loss was correlated between the upper and lower lids, and was associated with aging and gender. The MG loss and its morphologic changes correlated with many clinical ocular surface measurements, and thus, meibography will be important in assessing ocular surface conditions in patients with DED.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

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