September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Similarities and differences among primary, secondary and non Sjögren syndrome patients
Author Affiliations & Notes
  • Carolina Maria Modulo
    Department of Ophthalmology, School of Medicine of Ribeirão Preto - University of São Paulo, Ribeirão Preto, São Paulo, Brazil
  • Jacqueline Faustino
    Department of Ophthalmology, School of Medicine of Ribeirão Preto - University of São Paulo, Ribeirão Preto, São Paulo, Brazil
  • Caio Cezar Elias
    Department of Ophthalmology, School of Medicine of Ribeirão Preto - University of São Paulo, Ribeirão Preto, São Paulo, Brazil
  • Denny Marcos Garcia
    Department of Ophthalmology, School of Medicine of Ribeirão Preto - University of São Paulo, Ribeirão Preto, São Paulo, Brazil
  • Amanda Pires Barbosa
    Department of Ophthalmology, School of Medicine of Ribeirão Preto - University of São Paulo, Ribeirão Preto, São Paulo, Brazil
  • Bruno Campos Fróes Marangoni
    Department of Ophthalmology, School of Medicine of Ribeirão Preto - University of São Paulo, Ribeirão Preto, São Paulo, Brazil
  • Eduardo M Rocha
    Department of Ophthalmology, School of Medicine of Ribeirão Preto - University of São Paulo, Ribeirão Preto, São Paulo, Brazil
  • Footnotes
    Commercial Relationships   Carolina Modulo, None; Jacqueline Faustino, None; Caio Elias, None; Denny Garcia, None; Amanda Barbosa, None; Bruno Marangoni, None; Eduardo Rocha, Advisory Board Johnson&Johnson Brazil (P)
  • Footnotes
    Support  FAPESP, CNPq, FAEPA, NAP-FTO
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 5682. doi:
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      Carolina Maria Modulo, Jacqueline Faustino, Caio Cezar Elias, Denny Marcos Garcia, Amanda Pires Barbosa, Bruno Campos Fróes Marangoni, Eduardo M Rocha; Similarities and differences among primary, secondary and non Sjögren syndrome patients. Invest. Ophthalmol. Vis. Sci. 2016;57(12):5682.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To identify biomarkers of Sjögren’s syndrome (SS) exocrinopathy, this study compared ocular and clinical characteristics of patients with primary (SS1), secondary SS (SS2) and patients with dry eye symptoms but did not fit on the SS criteria (non SS).

Methods : SS1, SS2 and non SS patients according to the 2002 American-European Criteria for SS were compared. Evaluation included ocular, oral, clinical and laboratorial variables, and the OSDI and PHQ9 questionnaires. The SAS JMP Software, version 10.0 was used for statistic analysis.

Results : A total of 65 individuals were evaluated. The majority was women (92%). The average age was 54.6 ± 16.1 and similar among the groups. None of the dry eye tests were different among the 3 groups. The scores on OSDI and PHQ9 were also similar. Minor salivary gland focus score, SSa and SSb were significantly lower in Non SS (p=0.0168, 0.0047, 0.0024, respectively). Whole salivary flow was significantly lower in SS2 (p=0.0178). The quadratic discriminant analysis revealed that the combined tests correctly classified 90% of the patients in their groups (Wilks' Lambda = 0.332; p = 0.0082). The area under the ROC curve better classified SS2 (0.9349), followed by Non SS (0.92) and SS1 (0.76). The most relevant variables were respectively SSa, SSb, fluorescein staining, TFBUT, SG focus score and whole salivary flow.

Conclusions : The data revealed that SS1, SS2 and non SS are distinguishable conditions, however ocular tools or score questionnaires alone were not able to detect the differences among those groups.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

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