September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
The Correlation of Corneal Staining with Age and Years of Disease in Sjogren's Syndrome.
Author Affiliations & Notes
  • Barbara Caffery
    Toronto Eye Care, Toronto, Ontario, Canada
    Toronto Western Hospital, Toronto, Ontario, Canada
  • Jennifer Harthan
    Illinois College of Optometry, Chicago, Illinois, United States
  • Mira Acs
    Toronto Eye Care, Toronto, Ontario, Canada
  • Melissa Barnett
    University of California, Davis Eye Center, Sacramento, California, United States
  • Charles Edmonds
    Edmonds, Husz & Pemberton Eye Center, Tucson, Arizona, United States
  • Larisa Johnson-Tong
    University of California, Davis Eye Center, Sacramento, California, United States
  • Richard Maharaj
    eyeLABS Optometry and Dry Eye Clinic, Brampton, Ontario, Canada
  • Dominik Papinski
    Centre for Contact Lens Research, School of Optometry, University of Waterloo, Waterloo, Ontario, Canada
  • Bart Pemberton
    Edmonds, Husz & Pemberton Eye Center, Tucson, Arizona, United States
  • Sruthi Srinivasan
    Centre for Contact Lens Research, School of Optometry, University of Waterloo, Waterloo, Ontario, Canada
  • Footnotes
    Commercial Relationships   Barbara Caffery, None; Jennifer Harthan, None; Mira Acs, None; Melissa Barnett, None; Charles Edmonds, None; Larisa Johnson-Tong, None; Richard Maharaj, None; Dominik Papinski, None; Bart Pemberton, None; Sruthi Srinivasan, None
  • Footnotes
    Support  Canadian Sjogren's Syndrome Society, Labtician pharmaceuticals
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 5683. doi:
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      Barbara Caffery, Jennifer Harthan, Mira Acs, Melissa Barnett, Charles Edmonds, Larisa Johnson-Tong, Richard Maharaj, Dominik Papinski, Bart Pemberton, Sruthi Srinivasan; The Correlation of Corneal Staining with Age and Years of Disease in Sjogren's Syndrome.. Invest. Ophthalmol. Vis. Sci. 2016;57(12):5683.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : The natural history of dry eye in Sjogren’s syndrome (SS) is poorly documented. The purpose of this multi-center retrospective chart review was to measure the relationship between corneal fluorescein staining and age and years since diagnosis in SS patients.

Methods : SS charts from 6 North American clinical sites were identified by a dry eye diagnostic code. Starting with the first visit after diagnosis of SS, variables were recorded including: age, sex, year of diagnosis, type of practitioner who diagnosed, corneal staining with fluorescein and other clinical signs. A global staining score was created (0 (no dryness)-100 (Severe dryness)), derived by melding 2 scales (0-10 and mild,moderate,severe). Data from the 1st observed visit was analyzed. Pearson correlations between grade of corneal fluorescein staining of the worst eye and a) patient age and b) years since diagnosis were conducted by SPSS statistical package.

Results : 123 charts of SS patients were included: 115 (93.5%) female, average age 56.3 ±11.7 years (range 24 to 84 years) and average time since diagnosis 7.1±5.1 years (n = 74; range 0 to 17 years). SS diagnosis was made by rheumatologists in 59%, family practitioners in 4%, ophthalmology in 4% and dermatology in 1% of patients with 32% unknown. Corneal staining was conducted on 98.4% and present in 69.3% of patients. Global corneal staining was documented on a scale of 0 to 100. The average corneal staining score of the worst eye was 27.99±29.26 (range 0 to 75).
There was no significant correlation between grade of corneal staining worst eye and patient age (n=117, r=-0.085, p=0.36). There was a significant correlation between grade of corneal staining worst eye and years since diagnosis (n=74, r=0.369, p=0.001).

Conclusions : In these SS patients with a wide range of age and years since diagnosis, the grade of corneal fluorescein staining of the worst eye did not correlate with patient age, but was significantly correlated with years since diagnosis. These results suggest that dry eye, as represented by corneal fluorescein staining, does progress in Sjogren’s syndrome. Further longitudinal review of these charts will establish other risk factors for dry eye severity in these patients.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

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