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Inhee Moon, Eunyoung Choi, Wungrak Choi, Hyungoo Kang, Eung Kweon Kim, Hyung Keun Lee; The severity of blepharitis is the main factor influencing subjective ocular discomfort in dry eye patients. Invest. Ophthalmol. Vis. Sci. 2016;57(12):5697.
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© ARVO (1962-2015); The Authors (2016-present)
Althogh a number of clinical parameters are well known to examine dry eye (DE) disease, it has been substantially confused regarding which factor mostly affects the clinical discomfort in DE. Blepharitis is recognized as one of the leading cause of evaporative-type DE disease, but there was no previous large scale study to investigate the effect of blepharitis in DE symptoms. The purpose of this study was to evaluate the factors influencing subjective ocular discomfort in DE patients combined with blepharitis, and analyze which parameter is most related with the severity of blepharitis.
This investigation was a cross-sectional, clinical case study. The test population consisted of dry eye patients suffering mild to moderate blepharitis. Fifty one subjects aged 22 to 81 years were enrolled of whom thirty eight patients, seventy six eyes completed the investigation.A detailed assessment was conducted at the outpatient department, including history taking, Visual analog scale(VAS) pain scoring, ocular surface disease index(OSDI)questionnaire, blepharitis severity grading (score 0-3), conjunctival and corneal fluorescein staining (score 0-4), and tear break up time(TBUT) assessment.
The results revealed significant correlation between subjective symptoms and blepharitis severity. A significant (p=0.0018) increase in overall VAS score and OSDI score was recorded in dry eye patients with severe blepharitis. Other DE parameters were not significantly related with VAS and OSDI scores. Additionally conjunctival and corneal erosion grades were not correlated with the blepharitis severity. TBUT results also did not showed any statistical correlation with blepharitis grades.
Our results showed that blepharitis severity is the main factor influencing subjective ocular pain and discomfort in DE patients and blepharitis severity was not related with the known clinical parameters of DE. This study indicates that targeting treatment for blepharitis can significantly improve quality of life for patients suffering from dry eye disease.
This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.
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