September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Dry Eye Disease in a Norwegian-Danish Cohort of Congenital Aniridia
Author Affiliations & Notes
  • Erlend Christoffer Sommer Landsend
    Department of Ophthalmology, Oslo University Hospital, Oslo, Norway
  • Øygunn Aass Utheim
    Department of Ophthalmology, Oslo University Hospital, Oslo, Norway
  • Hilde Røgeberg Pedersen
    National Centre for Optics,Vision and Eye Care,Department of Optometry and Visual Science,Faculty of Health Sciences, University College of Southeast Norway, Kongsberg, Buskerud, Norway
  • Rigmor C Baraas
    National Centre for Optics,Vision and Eye Care,Department of Optometry and Visual Science,Faculty of Health Sciences, University College of Southeast Norway, Kongsberg, Buskerud, Norway
  • Neil S Lagali
    Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden
  • Darlene A Dartt
    Schepens Eye Research Institute, Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts, United States
  • Tor Paaske Utheim
    Unit of Regenerative Medicine, Oslo University Hospital, Oslo, Norway
    Department of Ophthalmology, Drammen Hospital, Drammen, Norway
  • Footnotes
    Commercial Relationships   Erlend Christoffer Landsend, None; Øygunn Utheim, None; Hilde Pedersen, None; Rigmor Baraas, None; Neil Lagali, None; Darlene Dartt, None; Tor Utheim, None
  • Footnotes
    Support  Hjalmar Schiøtz Grant. Norwegian Ophthalmology Association Pediatric Ophthalmology and Strabismus Grant
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 5701. doi:
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      Erlend Christoffer Sommer Landsend, Øygunn Aass Utheim, Hilde Røgeberg Pedersen, Rigmor C Baraas, Neil S Lagali, Darlene A Dartt, Tor Paaske Utheim; Dry Eye Disease in a Norwegian-Danish Cohort of Congenital Aniridia. Invest. Ophthalmol. Vis. Sci. 2016;57(12):5701.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To investigate the prevalence of dry eye disease in a Norwegian-Danish cohort of congenital aniridia.

Methods : A comprehensive dry eye examination was performed, including measurements of tear meniscus height, tear film osmolarity, interblink interval, tear film break up-time (TFBUT), fluorescein vital staining, Schirmer`s test, aesthesiometry, meibum quality and expressibility, and meibography. Data were presented as mean and standard deviation. The correlation coefficients were calculated using Pearson's correlation analysis. Correlations were considered significant for p < 0.05.

Results : Thirty-three patients with congenital aniridia were included, 21 women and 12 men. Median age was 32 (9 - 72) years. Tear meniscus height was 0.27 (+/-0.09) mm and 0.29 (+/-0.16) mm in the right eyes (o.d.) and left eyes (o.s.), respectively. Tear film osmolarity was 311 (+/-12) mOsms/L o.d. and 314 (+/-11) o.s., corresponding to an elevated level in 48% and 63% of the right and left eyes, respectively. TFBUT was 7 (+/-7) sec o.d. and 7 (+/-8) sec o.s., whereas interblink interval was 16 (+/-11). Vital staining score was 4 (+/-3) in both eyes. Schirmer I was 25 (+/-12) mm o.d. and 27 (+/-11) o.s. Corneal sensitivity (using Cochet-Bonnet aesthesiometer) was 48 (+/-17) mm o.d. and 49 (+/-15) mm o.s. Meibum quality was 4 (+/-0) and meibum expressibility (+/-2), and was the same bilaterally. Meibography showed gland dropout in one or more eyelids in 87% of the patients, while 13% had more than 50% drop out in all four eyelids. TFBUT and interblink interval correlated significantly (r=0.45 o.d and r= 0.44 o.s).

Conclusions : Sixty-three percent of the patients had an abnormally high osmolarity level, and 87% of the patients had some degree of gland dropout. Interestingly, despite the low mean age of this cohort, there was a high prevalence of dry eye disease.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

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