September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Novel OCT technique of noncontact infrared meibography compared with transillumination biomicroscopy in evaluation of meibomian glands. A clinical study
Author Affiliations & Notes
  • Maurizio Fossarello
    Ophthalmology, University of Cagliari, Cagliari, Italy
  • Franco Coronella
    Ophthalmology, University of Cagliari, Cagliari, Italy
  • Giommaria Satta
    Ophthalmology, University of Cagliari, Cagliari, Italy
  • Pietro Emanuele Napoli
    Ophthalmology, University of Cagliari, Cagliari, Italy
  • Footnotes
    Commercial Relationships   Maurizio Fossarello, None; Franco Coronella, None; Giommaria Satta, None; Pietro Emanuele Napoli, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 5706. doi:
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      Maurizio Fossarello, Franco Coronella, Giommaria Satta, Pietro Emanuele Napoli; Novel OCT technique of noncontact infrared meibography compared with transillumination biomicroscopy in evaluation of meibomian glands. A clinical study. Invest. Ophthalmol. Vis. Sci. 2016;57(12):5706.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To determine the agreement between the traditional lid transillumination procedure and a novel optical coherence tomography (OCT) technique for the assessment of meibomian glands (MGs) morphology.

Methods : Agreement between OCT and lid transillumination examination for the detection of drop-out (partial or complete loss of MGs) and microscopic changes (i.e. shortening, distortion, segmentation and entanglement) were evaluated in 41 patients with obstructive MGD (20 men, 21 women; age [mean ± standard deviation] 41.1 ± 8.1 years), and 45 control subjects (22 men, 23 women; 40.3 ± 7.5 years).

Results : Overall agreement for all morphological features was substantial (Cohen kappa coefficient = 0.77; p<0.001),The majority of disagreement occurred for cases with segmentation, where agreement was present in only 82% of eyes with adequate images for interpretation, and where OCT tended to diagnose more cases not detected by traditional lid transillumination (McNemar test, p<0.001).

Conclusions : Each method has its advantages but in general there was close agreement between these two meibographic techniques, particularly for MG dropout. These results support the reliability of our novel, simple and patient-friendly OCT technique of meibomian gland evaluation.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

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