September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Acute corneal toxicity of conjunctival disinfectants.
Author Affiliations & Notes
  • Daisuke Inoue
    opthalmolgy, Nagasaki University, Nagasaki City, Japan
  • Masafumi Uematsu
    opthalmolgy, Nagasaki University, Nagasaki City, Japan
  • Ryotaro Ueki
    opthalmolgy, Nagasaki University, Nagasaki City, Japan
  • Naoki Imamura
    opthalmolgy, Nagasaki University, Nagasaki City, Japan
  • Yasser Helmy Mohamed
    opthalmolgy, Nagasaki University, Nagasaki City, Japan
  • Azusa Fujikawa
    opthalmolgy, Nagasaki University, Nagasaki City, Japan
  • Takashi Kitaoka
    opthalmolgy, Nagasaki University, Nagasaki City, Japan
  • Footnotes
    Commercial Relationships   Daisuke Inoue, None; Masafumi Uematsu, None; Ryotaro Ueki, None; Naoki Imamura, None; Yasser Mohamed, None; Azusa Fujikawa, None; Takashi Kitaoka, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 5725. doi:
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    • Get Citation

      Daisuke Inoue, Masafumi Uematsu, Ryotaro Ueki, Naoki Imamura, Yasser Helmy Mohamed, Azusa Fujikawa, Takashi Kitaoka; Acute corneal toxicity of conjunctival disinfectants.. Invest. Ophthalmol. Vis. Sci. 2016;57(12):5725.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : It is very important to avoid endophthlmitis after intraocular surgery by disinfectant, but several disinfectants may sometimes be harmful for ocular surface. The purpose of this study is to investigate the corneal toxicity of three conjunctival disinfectants using transepithelial electrical resistance [TER].

Methods : Corneal TER changes after a 60-second exposure to 0.25% povidone-iodine [PI], 4-fold diluted polyvinyl alcohol-iodine [PAI], and 0.02% chlorhexidine gluconate [CG] were measured in living rabbits. Hank’s balanced salt solution was used as a control.

Results : The corneal TER after a 60-second exposure to CG decreased to 14.1 +/- 3.7%. This result was statiscally significant compared to other two disinfectants and control (p<0.05). No statistically significant differences were found among other groups.

Conclusions : We concluded that the corneal toxicity of chlorhexidine gluconate is higher than other two disinfectants.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

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