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Manuel F Bande, Laura Paniagua, Raquel Mansilla, Maria Santiago, Francisco Ruiz-Oliva, Maria Jose Blanco-Teijeiro, Maria Pardo, Antonio Piñeiro; Multiple neoplasms in patients with uveal melanoma: a retrospective single-center analysis. Invest. Ophthalmol. Vis. Sci. 2016;57(12):5896.
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© ARVO (1962-2015); The Authors (2016-present)
To study the prevalence of second primary cancers (SPC) in patients with uveal melanoma of our center and relate it to the rate of survival
A retrospective, descriptive study of the prevalence of SPC was undertaken on a cohort of patients with uveal melanoma diagnosed between the years 2000-2011
122 patients with treated uveal melanoma were followed up in the Ocular Oncology Unit at the Complexo Hospitalario Universitario de Santiago. 16 patients (13.1%) reported in their medical history one or more malign neoplasms. There was no statistically significant differences between the age of onset, sex, cell type , location of melanoma and the presence or not of secondary malignancies. The most frequent association is adenocarcinoma prostate in men and breast cancer in women. The retrospective cohort study for survival rate noted that the 5-year survival rate of patients with SPC was 76.8%, versus 67% for patients without SPC, not demonstrating a statistically significant difference (P> 0.05).
SPC in uveal melanoma patients in our area are relatively frequent, higher than those found in other series (COMS, 7.2%). Patients with synchronous tumours present equal survival rates, in part because the cause of mortality is often, in the main, the liver metastatic of uveal melanoma.
This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.
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