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Hokyung Choung, Jinho Lee, Namju Kim, Sang In Khwarg, Min Joung Lee, Young A Kim; Clinical and Histopathological Features of Intraocular Medulloepithelioma. Invest. Ophthalmol. Vis. Sci. 2016;57(12):5904.
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© ARVO (1962-2015); The Authors (2016-present)
To report the clinical, radiological, and histopathological findings in patients diagnosed with medulloepithelioma.
The medical records, radiologic images, and pathologic specimens of 5 children histopathologically diagnosed with medulloepithelioma at Seoul National University Hospital and Seoul National University Hospital Boramae Medical Center between January 2001 and December 2013 were retrospectively analyzed.
Mean age at diagnosis was 5.5 years (8 month–12 years). Only one child was female, the others were male. Three children underwent previous intraocular surgery. The children were evaluated with ultrasound (n=4), computed tomography (n=5), and magnetic resonance imaging (n=3). Nuclear bone scan was performed in all children. CT images showed enhancing tumor. There were 3 cases of calcification and absent of cystic changes. On T1-weighted MRI, the tumors were isointense or slightly hyperintense and showed marked Gadolinium enhancement. T2-weight MRI showed hypointense signals of the tumors. Only one patient had extraocular extension and orbital extension at the time of diagnosis. All five children had post enucleation follow-up ranging from 8 months to 9 years (mean 39 months).
There was no definite point of differential diagnosis from retinoblastoma. Although medulloepithelioma is more rare compared to retinoblastoma, it must be included in the differential diagnoses of pediatric intraocular mass.
This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.
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