September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Assessing total retinal blood flow in diabetic retinopathy using multi-plane en face Doppler optical coherence tomography
Author Affiliations & Notes
  • Alex David Pechauer
    Ophthalmology, Oregon Health & Science University, Portland, Oregon, United States
  • Liang Liu
    Ophthalmology, Oregon Health & Science University, Portland, Oregon, United States
  • Ou Tan
    Ophthalmology, Oregon Health & Science University, Portland, Oregon, United States
  • Maria A Parker
    Ophthalmology, Oregon Health & Science University, Portland, Oregon, United States
  • Thomas S Hwang
    Ophthalmology, Oregon Health & Science University, Portland, Oregon, United States
  • David J Wilson
    Ophthalmology, Oregon Health & Science University, Portland, Oregon, United States
  • David Huang
    Ophthalmology, Oregon Health & Science University, Portland, Oregon, United States
  • Yali Jia
    Ophthalmology, Oregon Health & Science University, Portland, Oregon, United States
  • Footnotes
    Commercial Relationships   Alex Pechauer, None; Liang Liu, None; Ou Tan, Carl Zeiss Meditec, Inc. (P), Optovue, Inc (F), Optovue, Inc (P); Maria Parker, None; Thomas Hwang, None; David Wilson, None; David Huang, Carl Zeiss Meditec, Inc. (P), Optovue, Inc. (F), Optovue, Inc. (I), Optovue, Inc. (P); Yali Jia, Optovue, Inc. (F), Optovue, Inc. (P)
  • Footnotes
    Support  NIH grants DP3 DK104397; R01 EY024544, R01 EY023285, P30 EY010572, and an unrestricted grant from Research to Prevent Blindness
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 5920. doi:
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      Alex David Pechauer, Liang Liu, Ou Tan, Maria A Parker, Thomas S Hwang, David J Wilson, David Huang, Yali Jia; Assessing total retinal blood flow in diabetic retinopathy using multi-plane en face Doppler optical coherence tomography. Invest. Ophthalmol. Vis. Sci. 2016;57(12):5920.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To assess total retinal blood flow (TRBF) in diabetic retinopathy (DR) using multi-plane en face Doppler optical coherence tomography (OCT).

Methods : A spectral OCT system (RTVue-XR) was used to scan a 2x2 mm area centered at the optic disc of human participants. Scans were repeated three times with each consisting of five consecutive volumes. Eyes were included if at least 8 of the combined 15 volumes were viable. The multi-plane en face Doppler OCT algorithm was used to generate a three-dimensional volumetric data set made of 195 en face planes. The TRBF was summed from the maximum flow values of each branching retinal vein at an optimized en face plane. Eyes with clinically diagnosed DR were grouped separately by disease severity according to the international clinical classification system. The Mann-Whitney test was used to compare flow values between DR groups and a healthy control group.

Results : A total of 70 eyes from 36 participants were scanned. Eight eyes were excluded due to poor image quality. The within-day repeatability of scans was 4.1% (coefficient of variation). There was no significant difference in the TRBF between the healthy group (46.2 ± 10.4 µL/min, mean ± population standard deviation, 28 eyes) and mild/moderate non-proliferative DR (42.1 ± 9.3 µL/min, 12 eyes). The TRBF’s from the severe non-proliferative DR (31.2 ± 9.4 µL/min, 12 eyes) and proliferative DR (20.1 ± 4.0 µL/min, 10 eyes) groups were significantly lower (p < 0.01) than that of the healthy group. TRBF was highly correlated with DR disease severity (r = -0.72, p < 0.001, Spearmen).

Conclusions : The novel multi-plane en face Doppler OCT method provided reliable measurements of TRBF in DR eyes. Retinal blood flow decreased with increasing severity of DR. This metric may be useful in the assessment of disease progression in the diabetic eye.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

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