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Jin A Choi, Seung-June Noh, Soon-Young Paik, Chankee Park; Altered T cell immunity in patients with Posner-Schlossmann syndrome. Invest. Ophthalmol. Vis. Sci. 2016;57(12):5999.
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© ARVO (1962-2015); The Authors (2016-present)
Posner-Schlossmann syndrome(PSS) is characterized by recurrent attacks of mild anterior uveitis associated with marked elevations of intraocular pressure(IOP). Our goal was to explore changes in T cell immunity in patients with PSS.
Peripheral blood samples were obtained at the hypertensive phase with aqueous inflammation in study patients(n=15), and during cataract surgery in controls(n=11). All patients underwent a serological screening for IgGs against herpes simplex virus and cytomegalovirus. The counts of each T-cell subpopulation were determined via flow cytometry. The concentrations of inflammatory cytokines were measured using Luminex multiplex bead immunoassay.
The baseline IOP of the PSS group was significantly higher than that of the control group(P<0.001) and the corneal endothelial cell count in the PSS group was significantly lower than that of the control group(P<0.001). The PSS group had a significantly lower absolute lymphocyte count (1,931±325 cells/mm2) than the control group (2,328±507 cells/mm2; P=0.041) and reduced numbers of CD4+ and CD8+ T cells (P=0.058 and 0.029, respectively). In the same group, the CD8+CD28- and CD8+CD57+ T cell numbers, indicating the T cell immunosenescence were marginally lower than in the control group (P=0.085 and 0.085, respectively). Serum IL-2, TGFβ1, and TGFβ2 levels were lower in the PSS than the control group (P=0.056, 0.012, and 0.062, respectively).
PSS patients do not appear to exhibit typical immune aging. Rather, PSS seems to be associated with systemic immune activation and relative lymphopenia. This is the first description of altered T cell immunity in PSS patients.
This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.
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