September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
African Descent and Glaucoma Evaluation Study (ADAGES) III: Vitamin D Levels are Associated with Severity of Primary Open Angle Glaucoma (POAG) in African
Author Affiliations & Notes
  • Yii-Der Ida Chen
    Pediatrics, Los Angeles Biomedical Research Institute, Torrance, California, United States
  • Xiuqing Guo
    Pediatrics, Los Angeles Biomedical Research Institute, Torrance, California, United States
  • Radha Ayyagari
    Department of Ophthalmology, Hamilton Glaucoma Center, Shiley Eye InstituteUCSD, San Diego, California, United States
  • Linda M Zangwill
    Department of Ophthalmology, Hamilton Glaucoma Center, Shiley Eye InstituteUCSD, San Diego, California, United States
  • Jeffrey M Liebmann
    Harkness Eye Institute, Columbia University Medical Center, New York, New York, United States
  • Christopher A Girkin
    School of Medicine, Univ of Alabama at Birmingham, Birmingham, Alabama, United States
  • Robert M Feldman
    Ruiz Department of Ophthalmology, University of Texas Health Science Center, Hoston, Texas, United States
  • Harvey Dubiner
    Eye Care Center Management, Inc, Marrow, Georgia, United States
  • Jerome I Rotter
    Pediatrics, Los Angeles Biomedical Research Institute, Torrance, California, United States
  • Robert N Weinreb
    Department of Ophthalmology, Hamilton Glaucoma Center, Shiley Eye InstituteUCSD, San Diego, California, United States
  • Footnotes
    Commercial Relationships   Yii-Der Chen, None; Xiuqing Guo, None; Radha Ayyagari, None; Linda Zangwill, Carl Zeiss Meditec, Inc (F), Heidelberg Engineering GmbH, (F), Optovue Inc (F), Topcon Medical System Inc (F); Jeffrey Liebmann, Alcon, Inc. (C), Allergan, Inc (C), Bausch & Lomb, Inc (F), Bausch & Lomb, Inc (C), Carl Zeiss Meditech, Inc (F), Carl Zeiss Meditech, Inc (C), Heidelberg Engineering, GmbH (F), Heidelberg Engineering, GmbH (C), National Eye Institute (F), Optovue, Inc (F), Reichert, Inc (F), Reichert, Inc (C), Topcon, Inc (F), Valeant Pharmaceutiicals, Inc (C); Christopher Girkin, Carl Zeiss Meditech, Inc (F), EyeSight Foundation of Alabama (F), Heidelberg Engineering, GmbH (F), National Eye Institute (F), Research to Prevent Blindness (F), SOLX (F); Robert Feldman, None; Harvey Dubiner, None; Jerome Rotter, None; Robert Weinreb, Alcon, Inc. (C), Allergan, Inc (C), bausch & Lomb, Inc (C), Carl Zeiss Meditec (F), carl Zeiss Meditech, Inc (C), Genentech (F), Heidelberg Engineering (F), Optovue (F), topcon (C), Topcon (F)
  • Footnotes
    Support  EY023704; Y19869; EY110008; EY021818; EY19869
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 6019. doi:
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      Yii-Der Ida Chen, Xiuqing Guo, Radha Ayyagari, Linda M Zangwill, Jeffrey M Liebmann, Christopher A Girkin, Robert M Feldman, Harvey Dubiner, Jerome I Rotter, Robert N Weinreb; African Descent and Glaucoma Evaluation Study (ADAGES) III: Vitamin D Levels are Associated with Severity of Primary Open Angle Glaucoma (POAG) in African. Invest. Ophthalmol. Vis. Sci. 2016;57(12):6019.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To evaluate possible association between serum Vitamin D levels and POAG and in a cohort of patients of African descent (AD).

Methods : A subset of the ADAGES III cohort, consisting of 201 patients with a diagnosis of POAG and 80 age-matched normal controls of self-reported AD, were included in this analysis. Blood samples and family history were obtained from each patient. All patients with a diagnosis of POAG had glaucomatous visual field damage or an optic disc photograph or clinical drawing clearly indicating POAG. Control subjects had intraocular pressures ≤ 21 mm Hg, no evidence of glaucomatous optic neuropathy based on a clinical exam, and no family history of POAG in 1st degree relatives. POAG patients were classified into ‘mild’ and ‘severe’ phenotypes based on the severity of their visual field damage, and were matched for age, gender, and history of hypertension and diabetes. Serum 25 (OH) Vitamin D levels were measured by ELISA. Association of serum Vitamin D levels with the development and severity of POAG was tested by ANOVA and paired t-Test.

Results : The early glaucoma group (‘mild’) comprising 89 subjects had a visual field mean deviation (MD) of better than -4.0 dB. The advanced glaucoma group had 112 subjects with visual field MD or worse than -10 dB. Comparison of the levels of serum Vitamin D between the mild, severe and control groups by ANOVA showed a significant difference among the three groups (p=0.016). Pair-wise t-test revealed that the mean (95% CI) levels of Vitamin D of subjects in the control (6.21±4.04 pg/mL) and mild phenotype (6.24±3.52 pg/mL) groups are significantly different from the levels observed in subjects with severe phenotype (5.01±2.82 pg/mL) (p=0.020 and 0.011, respectively). Whereas, the mean levels of serum Vitamin D in controls is not significantly different from the subjects with the mild phenotype

Conclusions : In this AD cohort, lower serum levels of vitamin D were present in subjects with advanced glaucoma compared to early glaucoma and normal subjects.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

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