September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Plasma omega 3 polyunsaturated fatty acids and macular pigment optical density in subjects at high risk for age-related macular degeneration: the Limpia Study.
Author Affiliations & Notes
  • Benedicte MJ Merle
    Inserm, U1219 Bordeaux Population Health Research Center, Bordeaux, France
    Université de Bordeaux, Bordeaux, France
  • Benjamin Buaud
    ITERG – Equipe Nutrition Métabolisme & Santé, Bordeaux, France
  • Jean-Francois Korobelnik
    Service d'Ophtalmologie, CHU de Bordeaux, Bordeaux, France
    Inserm, U1219 Bordeaux Population Health Research Center, Bordeaux, France
  • Marie-Noelle Delyfer
    Service d'Ophtalmologie, CHU de Bordeaux, Bordeaux, France
    Inserm, U1219 Bordeaux Population Health Research Center, Bordeaux, France
  • Marie B Rougier
    Service d'Ophtalmologie, CHU de Bordeaux, Bordeaux, France
  • Genevieve Chêne
    Pôle Santé Publique USMR, CHU de Bordeaux, Bordeaux, France
  • Carole Vaysse
    ITERG – Equipe Nutrition Métabolisme & Santé, Bordeaux, France
  • Catherine P Garcher
    Service d'Ophtalmologie, CHU de Dijon, Dijon, France
  • Cecile DelCourt
    Inserm, U1219 Bordeaux Population Health Research Center, Bordeaux, France
    Université de Bordeaux, Bordeaux, France
  • Footnotes
    Commercial Relationships   Benedicte Merle, Horus Pharma (C), Laboratoires Théa (C); Benjamin Buaud, None; Jean-Francois Korobelnik, Alcon (C), Alimera (C), Allergan (C), Bayer (C), Horus (C), Novartis (C), Roche (C), Thea (C), Zeiss (C); Marie-Noelle Delyfer, Allergan (C), Bayer (C), Laboratoires Théa (C), Novartis (C); Marie Rougier, Allergan (C), Bausch+Lomb (C), Bayer (C), Laboratoires Théa (C), Novartis (C); Genevieve Chêne, None; Carole Vaysse, None; Catherine Garcher, Alcon (C), Allergan (C), Bausch+Lomb (C), Bayer (C), Horus (C), Novartis (C), Roche (C), Théa (C); Cecile DelCourt, Allergan (C), Baush+Lomb (C), Laboratoires Théa (C), Novartis (C)
  • Footnotes
    Support  Laboratoires Théa and Institut Carnot Lisa
Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Benedicte MJ Merle, Benjamin Buaud, Jean-Francois Korobelnik, Marie-Noelle Delyfer, Marie B Rougier, Genevieve Chêne, Carole Vaysse, Catherine P Garcher, Cecile DelCourt; Plasma omega 3 polyunsaturated fatty acids and macular pigment optical density in subjects at high risk for age-related macular degeneration: the Limpia Study.. Invest. Ophthalmol. Vis. Sci. 201657(12):.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose : In numerous epidemiological studies, omega 3 polyunsaturated fatty acids (PUFAs) have been associated with a decreased risk of age-related macular degeneration (AMD). Beyond their structural, functional and neuroprotective roles, omega 3 PUFAs may favor the retinal accumulation of lutein and zeaxanthin and thus increase macular pigment optical density (MPOD). We examined the associations of MPOD with plasma omega 3 PUFAs in subjects with at least one parent affected by neovascular AMD.

Methods : The Limpia study is a double-blind, placebo controlled, prospective randomized clinical trial performed in 120 subjects. Subjects with at least one parent affected by neovascular AMD, aged 40-70, with a best corrected visual acuity >20/25, free of late AMD and other major eye conditions and with no use of supplement containing lutein or zeaxanthin the preceding year were recruited in Bordeaux and Dijon, France.
MPOD within 1° was measured at baseline by modified Heidelberg retinal analyzer (Heidelberg, Germany). Omega 3 PUFAs (alpha linolenic (ALA), eicosapentaenoic (EPA), docosapentaenoic (DPA) and docosahexaenoic acids (DHA)) from plasma phosphatidylcholine (PC) were measured by gas chromatography. Medical history and lifestyle data were collected from a face to face standardized questionnaire.
Associations of MPOD with plasma omega 3 PUFAs were assessed at the baseline examination, using mixed linear models adjusted for age, sex, center, body mass index, smoking, plasma HDL-cholesterol and plasma lutein+zeaxanthin.

Results : Among 120 subjects included in the Limpia study, 115 had complete data for our analyses. After multivariate adjustment, high MPOD was significantly associated with higher level of plasma DPA measured in PC (beta=0.187, 95%CI: 0.021,0.354; p=0.03). Plasma ALA, EPA and DHA measured in PC were not significantly associated with MPOD.

Conclusions : In the Limpia study, high MPOD within 1° was significantly associated with higher levels of DPA measured in plasma phosphatidylcholine.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×