September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Early Signs of Age-Related Macular Degeneration: Associations with Daily Intake of Vitamin A, C, E, Zinc and Copper in the Inter99 Eye Study
Author Affiliations & Notes
  • Michael Larsen
    Department of Ophthalmology, Rigshospitalet and University of Copenhagen, Copenhagen, Denmark
  • Allan Linneberg
    Research Centre for Prevention and Health, Rigshospitalet, Glostrup, Denmark
  • Ulla Toft
    Research Centre for Prevention and Health, Rigshospitalet, Glostrup, Denmark
  • Inger Christine Munch
    Department of Ophthalmology, Roskilde Hospital, Roskilde, Denmark
  • Footnotes
    Commercial Relationships   Michael Larsen, None; Allan Linneberg, None; Ulla Toft, None; Inger Christine Munch, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science September 2016, Vol.57, No Pagination Specified. doi:
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      Michael Larsen, Allan Linneberg, Ulla Toft, Inger Christine Munch; Early Signs of Age-Related Macular Degeneration: Associations with Daily Intake of Vitamin A, C, E, Zinc and Copper in the Inter99 Eye Study. Invest. Ophthalmol. Vis. Sci. 201657(12):.

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      © 2017 Association for Research in Vision and Ophthalmology.

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Abstract

Purpose : To investigate associations of very early of age-related macular degeneration (AMD) with daily intake of vitamin A / beta-carotene, vitamin E, vitamin C, zinc and copper and interaction with CFHY402H.

Methods : Cross-sectional study of 848 subjects from the Inter99 Eye Study baseline investigation in 1999. Subjects were aged 30-60 years. Daily intakes of vitamins, zinc, and copper were estimated based on information from a 198 item food frequency questionnaire. Digital grayscale fundus images were made in red-free illumination and graded for macular drusen >63 µm and numerous (>20) small, hard macular drusen as a mean of both eyes. Participants were genotypes for the Y402H polymorphism (rs1061170) in complement H.

Results : Higher intake of vitamin A increased the odds for having macular drusen >63 odds with an odds ratio (OR) of 1.82 (95CI 1.02-3.24) for participants in the top quartile compared with the lowest quartile of estimated daily vitamin A intake. There was an interaction with CFHY402H (P=0.038 for interaction) and among the 504 participant with CFHY402H, the odds of having macular drusen >63 µm were increased in the 2 highest quartiles of vitamin A intake with OR=2.58 (95CI 1.16 to 5.73, P=0.020) for the highest quartile and OR=3.27 (95CI 1.50 to 7.13, P=0.0029) for the second highest quartile compared with participants in the lowest quartile of vitamin A intake, adjusted for recruitment group, age, and sex. After further adjusting for total fat intake, energy intake, plasma cholesterol, BMI, smoking, alcohol intake, education, and physical activity the ORs were 3.08 (95CI 1.02 to 9.25, P=0.46) respectively 3.92 (1.46 to 10.5, P=0.0068).
Macular drusen >63µm were not significantly associated with the daily intake of beta-carotene, vitamin C, vitamin E and zinc. The odds of having numerous small hard drusen were significantly increased in the second lowest quartile of vitamin A intake compared with the lowest quartile (OR= 2.02 (CI95 1.13-3.62, p=0.018) but the odds were not increased in the top quartiles of vitamin A intake and there was no interaction with CFHY402H.

Conclusions : In this cross-sectional study macular drusen >63µm were more prevalent in subjects with higher intake of vitamin A in subjects with CFHY402H. The study supports that vitamin A is a risk factor for early AMD.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

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