September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Quality of corneas from the donors with neovascular age-related macular degeneration
Author Affiliations & Notes
  • Meidong Zhu
    Lions New South Wales Eye Bank and New South Wales Bone Bank, New South Wales Organ and Tissue Donate Service, Sydney, New South Wales, Australia
    Save Sight Institute, University of Sydney, Sydney, New South Wales, Australia
  • Wijeyanthy Wijeyakumar
    Sydney Institute of Vision Science, Sydney, New South Wales, Australia
    Save Sight Institute, University of Sydney, Sydney, New South Wales, Australia
  • Bobak Bahrami
    University of Sydney, Sydney, New South Wales, Australia
    Sydney Institute of Vision Science, Sydney, New South Wales, Australia
  • Jane Treloggen
    Lions New South Wales Eye Bank and New South Wales Bone Bank, New South Wales Organ and Tissue Donate Service, Sydney, New South Wales, Australia
  • Andrew Alexander Chang
    Sydney Institute of Vision Science, Sydney, New South Wales, Australia
    Save Sight Institute, University of Sydney, Sydney, New South Wales, Australia
  • Footnotes
    Commercial Relationships   Meidong Zhu, None; Wijeyanthy Wijeyakumar, None; Bobak Bahrami, None; Jane Treloggen, None; Andrew Chang, Alcon (C), Alcon (R), Bayer (C), Bayer (R), Novartis (C), Novartis (R)
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 6211. doi:
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    • Get Citation

      Meidong Zhu, Wijeyanthy Wijeyakumar, Bobak Bahrami, Jane Treloggen, Andrew Alexander Chang; Quality of corneas from the donors with neovascular age-related macular degeneration. Invest. Ophthalmol. Vis. Sci. 2016;57(12):6211.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose :
The quality of corneal tissues for transplantation from deceased donor eyes with neovascular age-related macular degeneration (nAMD) treated with anti-vascular endothelial growth factor (anti-VEGF) has not been evaluated. This study was to compare the quality of corneas obtained from nAMD donors with corneas from donors without retinal disease.

Methods : A retrospective data review using the Lions New South Wales Eye Bank database was performed. Eyes with nAMD treated with intravitreal anti-VEGF were analyzed. The Control group 1 included donors randomly selected by computer generated number block to match donors without retinal disease regardless of their age and gender. Control group 2 consisted of non-retinal disease donors with age and gender matched to the nAMD group. Corneas that met acceptance criteria for transplantation were processed with standard eye bank procedures and stored in organ culture media. Data from the nAMD group including the donor’s demography, endothelial density and viability, previous cataract surgery and anti-VEGF treatment were compared with the control groups with student t-test and Pearson’s correlations.

Results : Thirty-four eyes from 17 donors in each group were analyzed. The mean ages of donors in nAMD, control group 1 and 2 were 84.9±5.4, 56.8±17.6 and 84.8±5.5 years respectively (p<0.001 between nAMD and Control group 1). The acceptance rate for corneal transplantation in the nAMD and Control group 1 was 82.4% vs 85.3% (p= 0.24). This rate was significantly higher than Control group 2 (58.8%, p=0.02). The mean endothelial density was 2634.3±610.9 cells/mm2 in the nAMD group compared to 2996.1±474.8 and 2672.2±585.8 cells/mm2 in Control group 1 (p=0.06) and 2 (p=0.83). The mean cell viabilities in the three groups were 89.4%±11.6, 92.9%±7.4 and 91.3%±8.3, respectively (all p>0.05). History of cataract surgery was higher in the nAMD and Control group 2 than Control group 1 (both 61.7% vs 11.8%, p<0.01). Endothelial density negatively correlated with age and cataract surgery (r=-0.6 and -0.5, all p<0.05). No association was found between anti-VEGF therapy and tissue quality.

Conclusions : Corneas collected from deceased nAMD donors had comparable quality to that from general donors. Previous anti-VEGF therapy appeared to have no impact on corneal quality, however cataract surgery may decrease the corneal quality.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

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