September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Corneal thickness is not increased in severe preeclampsia compared with normotensive controls
Author Affiliations & Notes
  • Conrad Stern-Ascher
    Department of Ophthalmology, College of Physicians and Surgeons, Columbia University, New York, New York, United States
    Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina, United States
  • Cande Ananth
    Department of Obstetrics and Gynecology, College of Physicians and Surgeons, Columbia University, New York, New York, United States
    Department of Epidemiology, Joseph L. Mailman School of Public Health, Columbia University, New York, New York, United States
  • Victoria North
    Department of Ophthalmology, College of Physicians and Surgeons, Columbia University, New York, New York, United States
  • Aakriti Garg
    Department of Ophthalmology, College of Physicians and Surgeons, Columbia University, New York, New York, United States
  • Winston Lee
    Department of Ophthalmology, College of Physicians and Surgeons, Columbia University, New York, New York, United States
  • Ronald Wapner
    Department of Obstetrics and Gynecology, College of Physicians and Surgeons, Columbia University, New York, New York, United States
  • Srilaxmi Bearelly
    Department of Ophthalmology, College of Physicians and Surgeons, Columbia University, New York, New York, United States
  • Footnotes
    Commercial Relationships   Conrad Stern-Ascher, None; Cande Ananth, None; Victoria North, None; Aakriti Garg, None; Winston Lee, None; Ronald Wapner, CombiMatrix (S), Illumina (F), Perinatal Quality Foundation (S), Sequenom (F); Srilaxmi Bearelly, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 6217. doi:
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      Conrad Stern-Ascher, Cande Ananth, Victoria North, Aakriti Garg, Winston Lee, Ronald Wapner, Srilaxmi Bearelly; Corneal thickness is not increased in severe preeclampsia compared with normotensive controls. Invest. Ophthalmol. Vis. Sci. 2016;57(12):6217.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Visual disturbances complicate approximately 40% of preeclampsia cases, and are even used as part of the diagnostic criteria of severe preeclampsia (sPE). The majority of preeclampsia cases, however, lack changes evident on clinical exam. We tested whether central corneal thickness (CCT) differed between subjects diagnosed with sPE and normotensive controls in the immediate postpartum period using standard pachymetry.

Methods : In this IRB approved, matched case-control study, we recruited 25 subjects with sPE (cases) and 27 with normotensive pregnancies (NP; controls) during the postpartum period. Controls were matched to sPE cases on parity and race/ethnicity. Women with a clinical diagnosis of chronic or gestational hypertension, or those diagnosed with pregestational or gestational diabetes were excluded from the study. Pachymetry was used to measure corneal thickness at the center of the pupil. Any subjective visual disturbances experienced in the peripartum period were noted.

Results : Severe preeclampsia cases and normotensive controls were examined, on average, at a median (range) of 3 (1-14) and 2 (1-3) days postpartum, respectively (P<0.001). Mean (± standard deviation) CCT was 544 ± 44 µm (range 431-625) and 557 ± 25 µm (range 504-600) in sPE cases and NP controls, respectively (P=0.07). Of sPE cases, 14 (56%) reported visual changes as compared to 1 (3.7%) in the control group (P<0.001). Two-tailed Student’s t-test was used for statistical analyses.

Conclusions : These findings demonstrate a trend toward decreased CCT measurements in women with sPE compared to normotensive women in the immediate postpartum period. Further studies designed with a larger number of patients and matched examination time between cases and controls are necessary. Importantly, the role of hormonal and angiogenic factors that shape the association between CCT and preeclampsia may be targets worthy of investigation.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

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