Purchase this article with an account.
Hsueh-min Hsu, Chang-Hao Yang; Measurement of rod-mediated dark adaptation functions in patients with diabetic retinopathy. Invest. Ophthalmol. Vis. Sci. 2016;57(12):6322.
Download citation file:
© ARVO (1962-2015); The Authors (2016-present)
Delayed rod-mediated dark adaptation is reported as one of the characters of patients with diabetic retinopathy. We examined the dark adaptation function between patients with different severity of diabetic retinopathy.
Dark adaptation was performed by using the AdaptDx dark adaptometer (MacuLogix, Inc.) in an observational study among the groups: subjects with diabetic mellitus without diabetic retinopathy (N=23, mean age: 65), background diabetic retinopathy (N= 22, mean age: 71), proliferative diabetic retinopathy (N=25, mean age: 60) and healthy controls (N=30, mean age: 56). The rod-mediated dark adaptation was automatically measured after a photobleach with targets centered at 12° on the inferior vertical meridian. All subjects are ≥ 18 years old and with best corrected visual acuity ≥ 20/400. The speed of rod-mediated dark adaptation was characterized by the rod intercept time and the value is ≤ 6.5 minutes in normal healthy subjects. ANOVA and multiple comparison with Tukey HSD method were used to compare the differences between groups, and the significance difference was defined as p<0.05.
The rod intercept time of healthy controls, diabetic mellitus without diabetic retinopathy, background diabetic retinopathy, and proliferative diabetic retinopathy were 4.55± 4.3 minutes, 6.85± 6.3 minutes, 7.28± 4 minutes, and 9.1± 5.06 minutes, respectively. There were significant differences among the four groups (ANOVA, p< 0.01). Multiple comparisons with Tukey HSD showed there was a significant difference between healthy controls and patients with proliferative diabetic retinopathy (p< 0.01).
The results of this study revealed that there is a significant impairment of rod-mediated dark adaptation in patients with diabetic retinopathy, especially patients with proliferative diabetic retinopathy. Test of the function of rod-mediated dark adaptation may be a useful indicator to monitor progression of diabetic retinopathy.
This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.
This PDF is available to Subscribers Only