September 2016
Volume 57, Issue 12
Open Access
ARVO Annual Meeting Abstract  |   September 2016
Measurement of rod-mediated dark adaptation functions in patients with diabetic retinopathy
Author Affiliations & Notes
  • Hsueh-min Hsu
    Department of Ophthalmology, National Taiwan University Hospital, Taipei, Taiwan
  • Chang-Hao Yang
    Department of Ophthalmology, National Taiwan University Hospital, Taipei, Taiwan
  • Footnotes
    Commercial Relationships   Hsueh-min Hsu, None; Chang-Hao Yang, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science September 2016, Vol.57, 6322. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Hsueh-min Hsu, Chang-Hao Yang; Measurement of rod-mediated dark adaptation functions in patients with diabetic retinopathy
      . Invest. Ophthalmol. Vis. Sci. 2016;57(12):6322.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose : Delayed rod-mediated dark adaptation is reported as one of the characters of patients with diabetic retinopathy. We examined the dark adaptation function between patients with different severity of diabetic retinopathy.

Methods : Dark adaptation was performed by using the AdaptDx dark adaptometer (MacuLogix, Inc.) in an observational study among the groups: subjects with diabetic mellitus without diabetic retinopathy (N=23, mean age: 65), background diabetic retinopathy (N= 22, mean age: 71), proliferative diabetic retinopathy (N=25, mean age: 60) and healthy controls (N=30, mean age: 56). The rod-mediated dark adaptation was automatically measured after a photobleach with targets centered at 12° on the inferior vertical meridian. All subjects are ≥ 18 years old and with best corrected visual acuity ≥ 20/400. The speed of rod-mediated dark adaptation was characterized by the rod intercept time and the value is ≤ 6.5 minutes in normal healthy subjects. ANOVA and multiple comparison with Tukey HSD method were used to compare the differences between groups, and the significance difference was defined as p<0.05.

Results : The rod intercept time of healthy controls, diabetic mellitus without diabetic retinopathy, background diabetic retinopathy, and proliferative diabetic retinopathy were 4.55± 4.3 minutes, 6.85± 6.3 minutes, 7.28± 4 minutes, and 9.1± 5.06 minutes, respectively. There were significant differences among the four groups (ANOVA, p< 0.01). Multiple comparisons with Tukey HSD showed there was a significant difference between healthy controls and patients with proliferative diabetic retinopathy (p< 0.01).

Conclusions : The results of this study revealed that there is a significant impairment of rod-mediated dark adaptation in patients with diabetic retinopathy, especially patients with proliferative diabetic retinopathy. Test of the function of rod-mediated dark adaptation may be a useful indicator to monitor progression of diabetic retinopathy.

This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.

×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×